Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials
Heshmati J, Morvaridzadeh M, Maroufizadeh S, Akbari A, Yavari M, Amirinejad A, Maleki-Hajiagha A, Sepidarkish M
Pharmacological research · 139 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-09-26 · Pharmacol Res · vol. 149 · pág. 104462
- Editorial
- Elsevier BV
- Citado
- 208 citas · más que el 95% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 100 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 fatty acids, dietary supplementation, oxidative stress, antioxidants, total antioxidant capacity, glutathione peroxidase, malondialdehyde, nitric oxide, superoxide dismutase, reduced glutathione, lipid peroxidation, chronic disease prevention, blood glucose, serum lipids, cardiovascular risk factors, cognitive function, depression, anxiety
- MeSH
- humans, reactive oxygen species, malondialdehyde, glutathione peroxidase, fatty acids, omega-3, oxidative stress, dietary supplements, randomized controlled trials as topic
8 autores
- Javad Heshmati🇮🇷Kermanshah University of Medical Sciences
- Mojgan Morvaridzadeh🇮🇷Kermanshah University of Medical Sciences
- Saman Maroufizadeh🇮🇷Guilan University of Medical Sciences
- Abolfazl Akbari🇮🇷Iran University of Medical Sciences; Tehran University of Medical Sciences
- Mahsa Yavari🇺🇸Texas Tech University
- Ali Amirinejad🇮🇷Iran University of Medical Sciences
- Arezoo Maleki‐Hajiagha🇮🇷Tehran University of Medical Sciences
- Mahdi Sepidarkish🇮🇷 · autor de correspondenciaBabol University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Omega-3 fatty acids (omega-3 FAs) supplementation effects on oxidants and antioxidants are always controversial. Oxidative stress (OS) is one of the major mechanisms that contribute to the pathogenesis of several chronic diseases. The present systematic review and meta-analysis aimed to summarize the finding of randomized clinical trials (RCTs) examining the effects of omega-3 FAs on OS markers. Five databases including PubMed, Embase, Scopus, Web of science, and Cochrane were searched up to May 5th, 2019 with no language restriction. RCTs included if they compared OS indices among subjects who received omega-3 FAs supplements and subjects who supplemented with placebo. To estimate the effects of omega-3 FAs supplementation, standardized mean difference (SMD) with 95% confidence intervals (95% CI) were pooled using random effects model. Of 5,887 publications, 39 trials involving 2,875 participants were included for the meta-analysis. The pooled analysis of data indicated that omega-3 FAs significantly increased serum total antioxidant capacity (TAC) (SMD: 0.48, 95% CI: 0.23, 0.72, P2= 60%), glutathione peroxidase (GPx) (SMD: 0.73, 95% CI: 0.30, 1.16, P= 0.001; I2= 83%) activity and decreased malondialdehyde (MDA) (SMD= -0.42, 95% CI: -0.62, -0.21; P 2= 74%) compared to the placebo group. However, the effects of omega-3 FAs on nitric oxide (NO) (SMD: -0.17 , 95% CI: -0.77, 0.43, P = 0.57; I2= 91%), reduced glutathione (GSH) (SMD= 0.23, 95% CI= -0.17, 0.64, P= 0.25; I2= 75%), superoxide dismutase (SOD) (0.12 , 95% CI: -0.40, 0.65, P= 0.64; I2= 89%) and catalase (CAT) (0.16, 95% CI: -0.33, 0.65, P= 0.52; I2= 75%,) activities was not significant. Supplementation with omega-3 FAs significantly improves MDA, TAC levels, and GPx activity. Thus, omega-3 FAs can be mentioned as enhancer factors in antioxidant defense against reactive oxygen species (ROS).
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