Does Creatine Supplementation Affect Renal Function in Patients with Peripheral Artery Disease? A Randomized, Double Blind, Placebo-controlled, Clinical Trial
Domingues WJR, Ritti-Dias RM, Cucato GG, Wolosker N, Zerati AE, Puech-Leão P, Nunhes PM, Moliterno AA, Avelar A
Annals of vascular surgery · 7 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Fundacion Araucaria
- Organización sin fines de lucro
- Fundação Araucária
- Gobierno
- Fundação de Amparo à Pesquisa do Estado do Amazonas
- Subvenciones
- Fundacion Araucaria (002/2017); Fundação Araucária (#002/2017); Fundação de Amparo à Pesquisa do Estado do Amazonas (#062.03159.2014)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-09-26 · Ann Vasc Surg · vol. 63 · págs. 45–52
- Editorial
- Elsevier BV
- Citado
- 12 citas · más que el 57% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Peripheral Artery Disease Management · Dialysis and Renal Disease Management
- Palabras clave
- creatine monohydrate, creatine supplementation, peripheral arterial disease, renal function, creatinine clearance, serum creatinine, renal safety, dietary supplements, cardiovascular risk factors, diabetes mellitus, dyslipidemia, smoking, physical inactivity
- MeSH
- kidney, humans, creatine, creatinine, glomerular filtration rate, treatment outcome, double-blind method, time factors, dietary supplements, adult, aged, aged, 80 and over, middle aged, brazil, female, male, peripheral arterial disease, renal elimination
9 autores
- Wagner Jorge Ribeiro Domingues🇧🇷 · autor de correspondenciaUniversidade Federal do Amazonas
- Raphael Mendes Ritti‐Dias🇧🇷Universidade Nove de Julho
- Gabriel Grizzo Cucato🇧🇷Hospital Israelita Albert Einstein
- Nelson Wolosker🇧🇷Hospital Israelita Albert Einstein
- Antônio Eduardo Zerati
- Pedro Puech‐Leão🇧🇷Universidade de São Paulo
- Pollyana Mayara Nunhes🇧🇷Universidade Estadual de Maringá
- André Alberto Moliterno🇧🇷Universidade Estadual de Maringá
- Ademar Avelar🇧🇷Universidade Estadual de Maringá
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Case studies and reviews have shown that creatine supplementation can affect kidney function. The objective of this study is to verify the effects of 8 weeks of creatine supplementation on renal function (creatinine clearance: primary outcome) in patients with symptomatic peripheral arterial disease.
Methods
Twenty-nine patients, of both genders, were randomized (1:1) in a double-blind manner for administration of Placebo (PLA; n = 15) or creatine monohydrate (Cr; n = 14). The supplementation protocol consisted of 20 g/day for 1 week divided into 4 equal doses (loading phase), followed by single daily doses of 5 g in the subsequent 7 weeks (maintenance phase). Before and after the supplementation period, markers of renal function, serum creatinine, creatinine excretion rate, and creatinine clearance were evaluated. The Generalized Estimation Equation Model was used for comparison between groups. The level of significance was P < 0.05.
Results
No significant differences were found between groups before and after the intervention for serum creatinine (Cr: pre 1.00 ± 0.15 mL/dL vs. post 1.07 ± 0.16 mL/dL; PLA: pre 1.30 ± 0.53 mL/dL vs. post 1.36 ± 0.47 mL/dL, P = 0.590), creatinine excretion rate (Cr: pre 81.73 ± 43.80 mg/dL vs. post 102.92 ± 59.57 mg/dL; PLA: pre 74.37 ± 38.90 mg/dL vs. post 86.22 ± 39.94 mg/dL, P = 0.560), or creatinine clearance (Cr; pre 108 ± 59 mL/min/1.73 m2 vs. post 117 ± 52 mL/min/1.73 m2; PLA: pre 88 ± 49 mL/min/1.73 m2 vs. post 82 ± 47 mL/min/1.73 m2, P = 0.366).
Conclusions
Eight weeks of creatine supplementation is safe and does not compromise the renal function of patients with peripheral arterial disease.
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