Photobiomodulation therapy (PBMT) in bone repair: A systematic review
Escudero JSB, Perez MGB, de Oliveira Rosso MP, Buchaim DV, Pomini KT, Campos LMG, Audi M, Buchaim RL
Injury · 68 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-09-21 · Injury · vol. 50 · número 11 · págs. 1853–1867
- Editorial
- Elsevier BV
- Citado
- 110 citas · más que el 93% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Bone Tissue Engineering Materials · Biofield Effects and Biophysics
- Palabras clave
- low-level laser therapy, bone regeneration, bone defects, growth factors, bone formation, biomaterials, laser parameters, energy density, wavelength, cell proliferation, vascularization, inflammation
- MeSH
- fibroblasts, humans, collagen, bone regeneration, fracture healing, cell proliferation, osteogenesis, fractures, bone, low-level light therapy
8 autores
- José Stalin Bayas Escudero🇧🇷Universidade de São Paulo
- Maria Gabriela Benitez Perez🇧🇷Universidade de São Paulo
- Marcelie Priscila de Oliveira Rosso🇧🇷Universidade de São Paulo
- Daniela Vieira Buchaim🇧🇷Faculdade de Medicina de Marília; Universidade de São Paulo; Universidade de Marília; Centro Universitário de Adamantina
- Karina Torres Pomini🇧🇷Universidade de São Paulo
- Leila Maria Guissoni Campos🇧🇷Faculdade de Medicina de Marília; Universidade de Marília
- Mauro Audi🇧🇷Universidade de Marília
- Rogério Leone Buchaim🇧🇷 · autor de correspondenciaFaculdade de Medicina de Marília; Universidade de São Paulo; Universidade de Marília
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Photobiomodulation therapy (PBMT) using low-level laser influences the release of several growth factors involved in the formation of epithelial cells, fibroblasts, collagen and vascular proliferation, besides accelerating the synthesis of bone matrix due to the increased vascularization and lower inflammatory response, with significant increase of osteocytes in the irradiated bone. Considering its properties, beneficial effects and clinical relevance, the aim of this review was to analyze the scientific literature regarding the use of PBMT in the process of bone defect repair.
Methods
Electronic search was carried out in PubMed/MEDLINEⓇ and Web of Science databases with combination of the descriptors low-level laser therapy AND bone repair, considering the period of publication until the year 2018.
Results
The literature search identified 254 references in PubMed/MEDLINE and 204 in Web of Science, of which 33 and 4 were selected, respectively, in accordance with the eligibility requirements. The analysis of researches showed articles using PBMT in several places of experimentation in the subjects, different types of associated biomaterials, stimulatory effects on cell proliferation, besides variations in the parameters of use of laser therapy, mainly in relation to the wavelength and density of energy. Only four articles reported that the laser did not improve the osteogenic properties of a biomaterial.
Conclusions
Many studies have shown that PBMT has positive photobiostimulatory effects on bone regeneration, accelerating its process regardless of parameters and the use of biomaterials. However, standardization of its use is still imperfect and should be better studied to allow correct application concerning the utilization protocols.
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