Financiado en parte por Deltex Medical Ltd., Smiths Medical Ltd
Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude - A randomised controlled trial (Xtreme Alps)
Cumpstey AF, Hennis PJ, Gilbert-Kawai ET, Fernandez BO, Grant D, Jenner W, Poudevigne M, Moyses H, Levett DZ, Cobb A, Meale P, Mitchell K, Pöhnl H, Mythen MG, Grocott MP, Martin DS, Feelisch M
Nitric oxide : biology and chemistry · 7 citas
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Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- University of Southampton
- Universidad u hospital
- University of Warwick
- Universidad u hospital
- University College London Hospitals NHS Foundation Trust
- Gobierno
- Medical Research Council
- Universidad u hospital
- UCLH Biomedical Research Centre
- Universidad u hospital
- (University of Southampton Biomedical Research Centre)
- Gobierno
- Southampton NIHR BRC Fellowship
- Universidad u hospital
- Faculty of Medicine, University of Southampton
- Gobierno
- National Institute for Health Research (NIHR)
- Empresa
- Deltex Medical Ltd.
- Universidad u hospital
- University College Hospital NHS Foundation Trust
- Empresa
- Smiths Medical Ltd
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Medical Research Council (MR/P008887/1); National Institute for Health and Care Research (NIHR-INF-0832); National Institute for Health and Care Research (ACF-2015-26-003)
Según 13 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-10-08 · Nitric Oxide · vol. 94 · págs. 27–35
- Editorial
- Elsevier BV
- Citado
- 8 citas · más que el 77% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- High Altitude and Hypoxia · Nitric Oxide and Endothelin Effects · Cardiovascular and exercise physiology
- Palabras clave
- nitrate supplementation, beetroot, high altitude, hypobaric hypoxia, nitrite, microvascular blood flow, forearm blood flow, lowlanders, hypoxia tolerance, supplemental oxygen
- MeSH
- microcirculation, humans, altitude sickness, nitrates, nitrites, nitroso compounds, blood flow velocity, dietary supplements, adult, female, male, young adult
17 autores
- Andrew F. Cumpstey🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Philip J Hennis🇬🇧National Institute for Health and Care Research; University College London
- Edward T. Gilbert-Kawai🇬🇧National Institute for Health and Care Research; University College London
- Bernadette O. Fernandez🇬🇧University Hospital Southampton NHS Foundation Trust; University of Warwick; NIHR Southampton Biomedical Research Centre; University of Southampton
- Daniel Grant🇬🇧National Institute for Health and Care Research; University College London
- William John Jenner🇬🇧National Institute for Health and Care Research; University College London
- Matthieu Poudevigne🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Helen E. Moyses🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Denny Z H Levett🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Alexandra Cobb🇬🇧National Institute for Health and Care Research; University College London
- Paula Meale🇬🇧National Institute for Health and Care Research; University College London
- Kay Mitchell🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Helmut Pöhnl
- Monty G. Mythen🇬🇧National Institute for Health and Care Research; University College London
- Michael P. W. Grocott🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Daniel Martín🇬🇧 · autor de correspondenciaNational Institute for Health and Care Research; University College London
- Martin Feelisch🇬🇧 · autor de correspondenciaSouthampton General Hospital; University Hospital Southampton NHS Foundation Trust; University of Warwick; NIHR Southampton Biomedical Research Centre; University of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Native highlanders (e.g. Sherpa) demonstrate remarkable hypoxic tolerance, possibly secondary to higher levels of circulating nitric oxide (NO) and increased microcirculatory blood flow. As part of the Xtreme Alps study (a randomised placebo-controlled trial of dietary nitrate supplementation under field conditions of hypobaric hypoxia), we investigated whether dietary supplementation with nitrate could improve NO availability and microvascular blood flow in lowlanders. Plasma measurements of nitrate, nitrite and nitroso species were performed together with measurements of sublingual (sidestream dark-field camera) and forearm blood flow (venous occlusion plethysmography) in 28 healthy adult volunteers resident at 4559 m for 1 week; half receiving a beetroot-based high-nitrate supplement and half receiving an identically-tasting low nitrate 'placebo'. Dietary supplementation increased plasma nitrate concentrations 4-fold compared to the placebo group, both at sea level (SL; 19.2 vs 76.9 μM) and at day 5 (D5) of high altitude (22.9 vs 84.3 μM, p < 0.001). Dietary nitrate supplementation also significantly increased both plasma nitrite (0.78 vs. 0.86 μM SL, 0.31 vs. 0.41 μM D5, p = 0.03) and total nitroso product (11.3 vs. 19.7 nM SL, 9.7 vs. 12.3 nM D5, p < 0.001) levels both at sea level and at 4559 m. However, plasma nitrite concentrations were more than 50% lower at 4559 m compared to sea level in both treatment groups. Despite these significant changes, dietary nitrate supplementation had no effect on any measured read-outs of sublingual or forearm blood flow, even when environmental hypoxia was experimentally reversed using supplemental oxygen. In conclusion, dietary nitrate supplementation does not improve microcirculatory function at 4559 m.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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