Music Therapy Enhances Executive Functions and Prefrontal Structural Neuroplasticity after Traumatic Brain Injury: Evidence from a Randomized Controlled Trial
Siponkoski ST, Martínez-Molina N, Kuusela L, Laitinen S, Holma M, Ahlfors M, Jordan-Kilkki P, Ala-Kauhaluoma K, Melkas S, Pekkola J, Rodriguez-Fornells A, Laine M, Ylinen A, Rantanen P, Koskinen S, Lipsanen J, Särkämö T
Journal of neurotrauma · 58 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-10-23 · J Neurotrauma · vol. 37 · número 4 · págs. 618–634
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 126 citas · más que el 99% de estudios similares · 13.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 144 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Music Therapy and Health · Traumatic Brain Injury Research · Cognitive Functions and Memory
- Palabras clave
- music therapy, traumatic brain injury, executive function, set-shifting, prefrontal cortex, neuroplasticity, gray matter volume, inferior frontal gyrus, cognitive rehabilitation, Frontal Assessment Battery
- MeSH
- prefrontal cortex, humans, magnetic resonance imaging, music therapy, neuropsychological tests, neuronal plasticity, adult, middle aged, female, male, executive function, brain injuries, traumatic
17 autores
- Sini‐Tuuli Siponkoski🇫🇮 · autor de correspondenciaUniversity of Helsinki
- Noelia Martínez‐Molina🇫🇮University of Helsinki
- Linda Kuusela🇫🇮University of Helsinki; Helsinki University Hospital; Hospital District of Helsinki and Uusimaa
- Sari Laitinen
- Milla Holma
- Mirja Ahlfors
- Päivi Jordan-Kilkki
- Katja Ala-Kauhaluoma
- Susanna Melkas🇫🇮Helsinki University Hospital
- Johanna Pekkola🇫🇮University of Helsinki; Helsinki University Hospital; Hospital District of Helsinki and Uusimaa
- Antoni Rodríguez‐Fornells🇪🇸Institució Catalana de Recerca i Estudis Avançats; Institut d'Investigació Biomédica de Bellvitge; Universitat de Barcelona
- Matti Laine🇫🇮Åbo Akademi University
- Aarne Ylinen🇫🇮Helsinki University Hospital; Tampere University Hospital
- Pekka Rantanen🇫🇮Kanta-Hämeen Keskussairaala
- Sanna K. Koskinen🇫🇮University of Helsinki
- Jari Olavi Lipsanen🇫🇮University of Helsinki
- Teppo Särkämö🇫🇮University of Helsinki
Resumen
El texto original del estudio, en el idioma en que se publicó.
Traumatic brain injury (TBI) causes lifelong cognitive deficits, particularly impairments of executive functioning (EF). Musical training and music-based rehabilitation have been shown to enhance cognitive functioning and neuroplasticity, but the potential rehabilitative effects of music in TBI are still largely unknown. The aim of the present crossover randomized controlled trial (RCT) was to determine the clinical efficacy of music therapy on cognitive functioning in TBI and to explore its neural basis. Using an AB/BA design, 40 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB, n = 20) or second (BA, n = 20) half of a 6-month follow-up period. Neuropsychological and motor testing and magnetic resonance imaging (MRI) were performed at baseline and at the 3-month and 6-month stage. Thirty-nine subjects who participated in baseline measurement were included in an intention-to-treat analysis using multiple imputation. Results showed that general EF (as indicated by the Frontal Assessment Battery [FAB]) and set shifting improved more in the AB group than in the BA group over the first 3-month period and the effect on general EF was maintained in the 6-month follow-up. Voxel-based morphometry (VBM) analysis of the structural MRI data indicated that gray matter volume (GMV) in the right inferior frontal gyrus (IFG) increased significantly in both groups during the intervention versus control period, which also correlated with cognitive improvement in set shifting. These findings suggest that neurological music therapy enhances EF and induces fine-grained neuroanatomical changes in prefrontal areas.
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