Reported Side Effects, Weight and Blood Pressure, After Repeated Sessions of Transcranial Photobiomodulation
Cassano P, Caldieraro MA, Norton R, Mischoulon D, Trinh NH, Nyer M, Dording C, Hamblin MR, Campbell B, Iosifescu DV
Photobiomodulation, photomedicine, and laser surgery · 37 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-10-01 · Photobiomodul Photomed Laser Surg · vol. 37 · número 10 · págs. 651–656
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 45 citas · más que el 90% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Transcranial Magnetic Stimulation Studies · Biofield Effects and Biophysics
- Palabras clave
- transcranial photobiomodulation, near-infrared light, major depressive disorder, treatment safety, weight change, blood pressure, diastolic blood pressure, light-emitting diodes
- MeSH
- brain, humans, hypertension, body weight, blood pressure determination, severity of illness index, chi-square distribution, statistics, nonparametric, double-blind method, infrared rays, pregnancy, adult, middle aged, hospitals, general, boston, female, male, low-level light therapy, major depressive disorder
10 autores
- Paolo Cassano🇺🇸 · autor de correspondenciaMassachusetts General Hospital
- Marco Antônio Caldieraro🇧🇷Hospital de Clínicas de Porto Alegre
- Richard Norton🇺🇸Massachusetts General Hospital
- David Mischoulon🇺🇸Massachusetts General Hospital
- Nhi‐Ha Trinh🇺🇸Massachusetts General Hospital
- Maren Nyer🇺🇸Massachusetts General Hospital
- Christina M. Dording🇺🇸Massachusetts General Hospital
- Michael R. Hamblin🇺🇸Massachusetts General Hospital
- Benjamin Campbell🇺🇸Massachusetts General Hospital
- Dan Vlad Iosifescu🇺🇸Nathan Kline Institute for Psychiatric Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Transcranial photobiomodulation (t-PBM) consists in the delivery of near-infrared light (NIR) to the scalp, directed to cortical areas of the brain. NIR t-PBM recently emerged as a potential therapy for depression, although safety of repeated treatments has not been adequately explored. Objective: This study assessed incidence of side effects, including weight and blood pressure changes, during repeated sessions of NIR t-PBM using a light-emitting diode source. Methods: We performed a secondary analysis of a double-blind clinical trial on t-PBM for major depressive disorder. Eighteen individuals received NIR t-PBM (n = 9) or sham (n = 9) twice weekly for 8 weeks. Side effects were assessed using the Systematic Assessment for Treatment-Emergent Effects-Specific Inquiry. In 14 individuals (nNIR = 6 vs. nsham = 8), body weight and systemic blood pressure were recorded at baseline and end-point. Results: More subjects in the NIR t-PBM group experienced side effects compared to sham, but only a trend for statistical significance was observed (χ2 = 3.60; df = 1; p = 0.058). The rate of side effects described by participants as "severe" in intensity was low and similar between the treatment groups (χ2 = 0.4; df = 1; p = 0.53), with no serious adverse events. Most side effects resolved during the study and treatment interruption were not required. Changes in weight and systolic blood pressure across groups were neither significant nor approached significance. In the NIR t-PBM group, diastolic blood pressure increased and reached statistical-however not clinical-significance (5.67 ± 7.26 vs. -6.13 ± 6.88; z = -2.40, p = 0.016). Conclusions: This small-sample, exploratory study indicates repeated sessions of NIR t-PBM might be associated with treatment-emergent side effects. The systemic metabolic and hemodynamic profile of repeated t-PBM appeared benign. Future studies with larger samples and longer follow-up are needed to more accurately determine the side-effect profile and safety of NIR t-PBM.
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