Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity
Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, Qi Y, Shi J, Qi S, Bao Y, Nie G
ACS nano · 111 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Prevention Research Trust
- Organización sin fines de lucro
- Academy of Medical Sciences
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Chinese Academy of Sciences
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Organización sin fines de lucro
- K. C. Wong Education Foundation
- Universidad u hospital
- Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Subvenciones
- National Natural Science Foundation of China (2016YFA0201600); National Natural Science Foundation of China (31571021); K. C. Wong Education Foundation (GJTD2018-03); Chinese Academy of Sciences (2018YFA0208900); Chinese Academy of Sciences (2016YFA0201600); National Natural Science Foundation of China (11621505); Chinese Academy of Sciences (11621505); National Natural Science Foundation of China (QYZDJ‐SSW‐SLH022); Academy of Medical Sciences (NAF003\1002); Chinese Academy of Sciences (QYZDJ-SSW-SLH022); Ministry of Science and Technology of the People's Republic of China (2016YFA0201600); National Natural Science Foundation of China (2018YFA0208900); Ministry of Science and Technology of the People's Republic of China (2018YFA0208900)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2019-10-31 · ACS Nano · vol. 13 · número 11 · págs. 13445–13455
- Editorial
- American Chemical Society
- Citado
- 147 citas · más que el 99% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Chemotherapy-induced organ toxicity mitigation · Genomics, phytochemicals, and oxidative stress · Sulfur Compounds in Biology
- Palabras clave
- Sulforaphane, Cisplatin, Glutathione, Nanoparticle, Chemistry, Biophysics, Nanotechnology, Combinatorial chemistry, Biochemistry, Materials science, Enzyme, Chemotherapy, Medicine, Biology
- MeSH
- tumor cells, cultured, animals, mice, inbred balb c, humans, mice, mice, nude, breast neoplasms, liver neoplasms, experimental, mammary neoplasms, experimental, cisplatin, isothiocyanates, sulfoxides, polymers, glutathione, antineoplastic agents, drug screening assays, antitumor, apoptosis, cell proliferation, cell survival, female, nanoparticles, hep g2 cells, mcf-7 cells, optical imaging
11 autores
- Ying Xu🇨🇳Sino-Danish Centre for Education and Research; National Center for Nanoscience and Technology; University of Chinese Academy of Sciences
- Xuexiang Han🇨🇳National Center for Nanoscience and Technology; University of Chinese Academy of Sciences; Tsinghua University
- Yiye Li🇨🇳 · autor de correspondenciaNational Center for Nanoscience and Technology; University of Chinese Academy of Sciences
- Huan Min🇨🇳National Center for Nanoscience and Technology
- Xiao Zhao🇨🇳National Center for Nanoscience and Technology; University of Chinese Academy of Sciences
- Yinlong Zhang🇨🇳National Center for Nanoscience and Technology; University of Chinese Academy of Sciences
- Yingqiu Qi🇨🇳Zhengzhou University
- Jian Ying Shi🇨🇳National Center for Nanoscience and Technology; University of Chinese Academy of Sciences
- Sheng Qi🇬🇧University of East Anglia
- Yongping Bao🇬🇧 · autor de correspondenciaUniversity of East Anglia
- Guangjun Nie🇨🇳 · autor de correspondenciaNational Center for Nanoscience and Technology; University of Chinese Academy of Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Platinum (Pt)-based chemotherapy is a broadly used therapeutic regimen against various cancers. However, the insufficient cellular uptake, deactivation by thiol-containing species and nonspecific distribution of cisplatin (CDDP) result in its low chemosensitivity as well as systemic side effects, which can largely constrain the employment of CDDP in clinical treatment. To circumvent these problems, in this study, polymeric nanoparticles were utilized to codeliver a water-soluble CDDP derivative, poly(γ,l-glutamic acid)-CDDP conjugate, and a naturally occurring compound derived from broccoli, sulforaphane, which can achieve efficient glutathione (GSH) depletion, to improve the accumulation of CDDP in cancer cells. Results show that compared with combinational treatment of CDDP and SFN, the nanoparticles were more effectively internalized and could significantly reduce GSH content in breast cancer cells, leading to a notable increase in DNA-bound Pt and DNA damage-induced apoptosis. Moreover, in an orthotopic breast cancer model, the nanoparticles achieved a significantly higher tumor accumulation and exhibited a more powerful antitumor activity. Finally, this nanoenhanced chemotherapy was further confirmed in a liver cancer model with high-expression of GSH. Taken together, this sulforaphane-based nanostrategy holds great promise to enhance the sensitivity and therapeutic efficacy of Pt-based chemotherapy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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