Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review
Marshall NS, Serinel Y, Killick R, Child JM, Raisin I, Berry CM, Lallukka T, Wassing R, Lee RW, Ratnavadivel R, Vedam H, Grunstein R, Wong KK, Hoyos CM, Cayanan EA, Comas M, Chapman JL, Yee BJ
Sleep medicine reviews · 18 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Academy of Finland
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (APP: 1152945); National Health and Medical Research Council (1060992); Academy of Finland (319200); Academy of Finland (#287488)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-10-16 · Sleep Med Rev · vol. 48 · pág. 101218
- Editorial
- Elsevier BV
- Citado
- 33 citas · más que el 45% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Restless Legs Syndrome Research · Magnesium in Health and Disease · Sleep and related disorders
- Palabras clave
- magnesium supplementation, restless legs syndrome, periodic limb movement disorder, leg cramps, sleep disorders, treatment efficacy
- MeSH
- humans, nocturnal myoclonus syndrome, restless legs syndrome, magnesium, polysomnography, dietary supplements
18 autores
- Nathaniel S. Marshall🇦🇺 · autor de correspondenciaThe University of Sydney; Woolcock Institute of Medical Research
- Yasmina Serinel🇦🇺The University of Sydney; Woolcock Institute of Medical Research; Nepean Hospital
- Roo Killick🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Julia Child🇦🇺The University of Sydney
- Isabelle Raisin🇦🇺The University of Sydney
- Callum M. Berry🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Tea M. Lallukka🇦🇺🇫🇮The University of Sydney; University of Helsinki; Woolcock Institute of Medical Research
- Rick Wassing🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Richard W. W. Lee🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Rajeev Ratnavadivel🇦🇺Central Coast Local Health District; University of Newcastle Australia
- Hima Vedam🇦🇺Liverpool Hospital; UNSW Sydney; Ingham Institute
- Ronald R. Grunstein🇦🇺The University of Sydney; Royal Prince Alfred Hospital; Woolcock Institute of Medical Research
- KEITH K. H. WONG🇦🇺The University of Sydney; Royal Prince Alfred Hospital; Woolcock Institute of Medical Research
- Camilla M. Hoyos🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Elizabeth A. Cayanan🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Maria Comas🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Julia L. Chapman🇦🇺The University of Sydney; Woolcock Institute of Medical Research
- Brendon John Yee🇦🇺The University of Sydney; Royal Prince Alfred Hospital; Woolcock Institute of Medical Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium supplementation is often suggested for restless legs syndrome (RLS) or period limb movement disorder (PLMD) based on anecdotal evidence that it relieves symptoms and because it is also commonly recommended for leg cramps. We aimed to review all articles reporting the effects of magnesium supplementation on changes in RLS and/or PLMD. We conducted a systematic search looking for all relevant articles and then two reviewers read all article titles and abstracts to identify relevant studies. Eligible studies were scored for their quality as interventional trials. We found 855 abstracts and 16 of these could not be definitively excluded for not addressing all aspects of our research question. Seven full-text articles were unlocatable and one was ineligible which left eight studies with relevant data. One was a randomised placebo-controlled trial, three were case series and four were case studies. The RCT did not find a significant treatment effect of magnesium but may have been underpowered. After quality appraisal and synthesis of the evidence we were unable to make a conclusion as to the effectiveness of magnesium for RLS/PLMD. It is not clear whether magnesium helps relieve RLS or PLMD or in which patient groups any benefit might be seen.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.