Cognitive Enhancement by Transcranial Photobiomodulation Is Associated With Cerebrovascular Oxygenation of the Prefrontal Cortex
Holmes E, Barrett DW, Saucedo CL, O'Connor P, Liu H, Gonzalez-Lima F
Frontiers in neuroscience · 54 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Texas at Austin
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-10-18 · Front Neurosci · vol. 13 · pág. 1129
- Editorial
- Frontiers Media
- Citado
- 83 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Optical Imaging and Spectroscopy Techniques · Migraine and Headache Studies
- Palabras clave
- Prefrontal cortex, Functional near-infrared spectroscopy, Transcranial direct-current stimulation, Neuroscience, Oxygenation, Neurocognitive, Deoxygenated Hemoglobin, Cognition, Effects of sleep deprivation on cognitive performance, Medicine, Psychology, Working memory, Stimulation, Internal medicine, Hemoglobin
6 autores
- Emma E. Holmes🇺🇸The University of Texas at Austin
- Douglas W. Barrett🇺🇸The University of Texas at Austin
- Celeste L. Saucedo🇺🇸The University of Texas at Austin
- Patrick J. O’Connor🇺🇸The University of Texas at Austin
- Hanli Liu🇺🇸The University of Texas at Arlington
- Francisco Gonzalez-Lima🇺🇸 · autor de correspondenciaThe University of Texas at Austin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Transcranial infrared laser stimulation (TILS) is a novel, safe, non-invasive method of brain photobiomodulation. Laser stimulation of the human prefrontal cortex causes cognitive enhancement. To investigate the hemodynamic effects in prefrontal cortex by which this cognitive enhancement occurs, we used functional near-infrared spectroscopy (fNIRS), which is a safe, non-invasive method of monitoring hemodynamics. We measured concentration changes in oxygenated and deoxygenated hemoglobin, total hemoglobin and differential effects in 18 healthy adults during sustained attention and working memory performance, before and after laser of the right prefrontal cortex. We also measured 16 sham controls without photobiomodulation. fNIRS revealed large effects on prefrontal oxygenation during cognitive enhancement post-laser and provided the first demonstration that cognitive enhancement by transcranial photobiomodulation is associated with cerebrovascular oxygenation of the prefrontal cortex. Sham control data served to rule out that the laser effects were due to pre-post task repetition or other non-specific effects. A laser-fNIRS combination may be useful to stimulate and monitor cerebrovascular oxygenation associated with neurocognitive enhancement in healthy individuals and in those with prefrontal hypometabolism, such as in cognitive aging, dementia and many neuropsychiatric disorders.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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