Relations of magnesium intake to cognitive impairment and dementia among participants in the Women's Health Initiative Memory Study: a prospective cohort study
Lo K, Liu Q, Madsen T, Rapp S, Chen JC, Neuhouser M, Shadyab A, Pal L, Lin X, Shumaker S, Manson J, Feng YQ, Liu S
BMJ open · 28 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- Women's Health Initiative
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1TR001863Ð); U.S. Department of Health and Human Services (HHSN268201600002 C); National Institutes of Health (HHSN268201600018C); National Heart, Lung, and Blood Institute (HHSN268201600018C); National Institute on Aging (HHSN-271-2011-00004C,); U.S. Department of Health and Human Services (HHSN268201600018 C); National Heart, Lung, and Blood Institute (K23HL140081); National Institute on Aging (HHSN26820044221C); Women's Health Initiative (HHSN268201600018C); Women's Health Initiative (HHSN271201100004C); National Heart, Lung, and Blood Institute (HHSN268201600004C); U.S. Department of Health and Human Services (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN271201100004C); Women's Health Initiative (HHSN268201600002C); National Institutes of Health (HHSN268201600003C); U.S. Department of Health and Human Services (HHSN-271-2011-00004C); National Institutes of Health (HHSN268201600004C); National Institutes of Health (HHSN271201100004C); Women's Health Initiative (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN26820044221C); U.S. Department of Health and Human Services (HHSN268201600004 C); National Heart, Lung, and Blood Institute (HHSN268201600003C); National Institutes of Health (HHSN268201600002C); Women's Health Initiative (HHSN268201600004C); National Heart, Lung, and Blood Institute (HHSN268201600002C)
Según 9 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-11-01 · BMJ Open · vol. 9 · número 11 · pág. e030052
- Editorial
- BMJ
- Citado
- 31 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Nutritional Studies and Diet
- Palabras clave
- Medicine, Dementia, Prospective cohort study, Women's Health Initiative, Cohort, Cohort study, Epidemiology, Gerontology, Cognitive decline, Body mass index, Multivariate analysis, Cognition, Internal medicine, Observational study, Psychiatry, Disease
- MeSH
- humans, dementia, magnesium, diet, cohort studies, prospective studies, memory, postmenopause, dietary supplements, aged, female, surveys and questionnaires, cognitive dysfunction
13 autores
- Kenneth Lo🇺🇸🇨🇳 · autor de correspondenciaBrown University; Guangdong Academy of Medical Sciences; Guangdong Provincial People's Hospital; South China University of Technology
- Qing Liu🇺🇸 · autor de correspondenciaBrown University
- Tracy Madsen🇺🇸Brown University
- Steve Rapp🇺🇸Wake Forest University
- Jiu‐Chiuan Chen🇺🇸University of Southern California
- Marian L. Neuhouser🇺🇸Fred Hutch Cancer Center
- Aladdin H. Shadyab🇺🇸University of California San Diego
- Lubna Pal🇺🇸Yale University
- Xiaochen Lin🇺🇸Brown University
- Sally Ann Shumaker🇺🇸Wake Forest University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital
- Yingqing Feng🇨🇳 · autor de correspondenciaGuangdong Academy of Medical Sciences; Guangdong Provincial People's Hospital; South China University of Technology
- Simin Liu🇺🇸 · autor de correspondenciaBrown University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the associations of dietary and supplemental magnesium (Mg) as assessed by a semi-quantitative food frequency questionnaire with cognitive outcomes among ageing women.
Design
This work conducts a prospective cohort study of participants enrolled in the Women's Health Initiative Memory Study (WHIMS), which was subsequently extended and named WHIMS-Epidemiology of Cognitive Health.
Setting
Forty clinical centres in the USA.
Participants
Postmenopausal women aged 65-79 years without dementia on enrolment.
Main outcome measures
Physician-adjudicated mild cognitive impairment (MCI) and/or probable dementia (PD).
Results
Participants were excluded (n=1006) if they had extreme values of dietary energy intake, had missing or extreme body mass index values, with prevalent MCI/PD at baseline, received only one cognitive assessment or had been followed up for 20 years of follow-up, 765 (11.8%) out of 6473 participants developed MCI/PD. For MCI/PD and MCI, the risks tended to be lower among participants in quintiles Q2-Q5 of Mg consumption compared with those in the lowest quintile. Participants in Q3 had a significantly lower risk of MCI/PD (HR 0.69, 95% CI 0.53 to 0.91) and MCI (HR 0.63, 95% CI 0.45 to 0.87) after multivariate adjustments. No significant association was observed between total Mg intake and PD. The association between total Mg intake, MCI/PD and MCI was non-linear as suggested by the likelihood test.
Conclusions
Total Mg intake between the estimated average requirement and the recommended dietary allowances may associate with a lower risk of MCI/PD and MCI.
Trial registration number
NCT00685009.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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