Role of Prophylactic Magnesium Supplementation in Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting: a Systematic Review and Meta-Analysis of 20 Randomized Controlled Trials
Chaudhary R, Garg J, Turagam M, Chaudhary R, Gupta R, Nazir T, Bozorgnia B, Albert C, Lakkireddy D
Journal of atrial fibrillation · 20 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-06-01 · J Atr Fibrillation · vol. 12 · número 1 · pág. 2154
- Citado
- 35 citas · más que el 65% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Atrial Fibrillation Management and Outcomes · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Randomized controlled trial, Atrial fibrillation, Placebo, Meta-analysis, Subgroup analysis, Relative risk, Artery, Anesthesia, Internal medicine, Surgery, Cardiology, Confidence interval
9 autores
- Rahul Chaudhary🇺🇸Mayo Clinic in Arizona
- Jalaj Garg🇺🇸Medical College of Wisconsin; Texas Cardiac Arrhythmia
- Mohit K. Turagam🇺🇸Mount Sinai Hospital
- Rohit Chaudhary🇺🇸Mayo Clinic in Arizona
- Rahul Gupta🇺🇸Westchester Medical Center; New York Medical College
- Talha F Nazir🇺🇸Lehigh Valley Hospital-Pocono; Lehigh Valley Health Network
- Babak Bozorgnia🇺🇸Lehigh Valley Hospital-Pocono; Lehigh Valley Health Network
- Christine M. Albert🇺🇸Lehigh Valley Hospital-Pocono; Lehigh Valley Health Network
- Dhanunjaya Lakkireddy🇺🇸Heart Rhythm Society; Kansas City Heart Rhythm Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Several randomized trials have evaluated the efficacy of prophylactic magnesium (Mg) supplementation in prevention of post-operative atrial fibrillation (POAF) in patients undergoing cardiac artery bypass grafting (CABG). We aimed to determine the role of prophylactic Mg in 3 different settings (intraoperative, postoperative, intraoperative plus postoperative) in prevention of POAF.
Methods
A systemic literature search was performed (until January 19, 2019) using PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to identify trials evaluating Mg supplementation post CABG. Primary outcome of our study was reduction in POAF post CABG.
Results
We included a total of 2,430 participants (1,196 in the Mg group and 1,234 in the placebo group) enrolled in 20 randomized controlled trials. Pooled analysis demonstrated no reduction in POAF between the two groups (RR 0.90; 95% CI, 0.79-1.03; p=0.13; I2=42.9%). In subgroup analysis, significant reduction in POAF was observed with postoperative Mg supplementation (RR 0.76; 95% CI, 0.58-0.99; p=0.04; I2=17.6%) but not with intraoperative or intraoperative plus postoperative Mg supplementation (RR 0.77; 95% CI, 0.49-1.22; p = 0.27; I2=49% and RR 0.92; 95% CI, 0.68-1.24; p = 0.58; I2=51.8%, respectively).
Conclusions
Magnesium supplementation, especially in the postoperative period, is an effective strategy in reducing POAF following CABG.
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