The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies
Gholami F, Moradi G, Zareei B, Rasouli MA, Nikkhoo B, Roshani D, Ghaderi E
BMC cardiovascular disorders · 60 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Kurdistan University Of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-11-07 · BMC Cardiovasc Disord · vol. 19 · número 1 · pág. 248
- Editorial
- BioMed Central
- Citado
- 82 citas · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 94 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Vitamin K Research Studies
- Palabras clave
- Medicine, Relative risk, Prospective cohort study, Vitamin D and neurology, Hazard ratio, Internal medicine, Incidence (geometry), vitamin D deficiency, Cohort study, Meta-analysis, Angiology, Confidence interval
- MeSH
- humans, cardiovascular diseases, vitamin d deficiency, vitamin d, prognosis, incidence, risk assessment, risk factors, prospective studies, adult, aged, aged, 80 and over, middle aged, female, male, young adult, biomarkers
7 autores
- Fatemeh Gholami🇮🇷Iran University of Medical Sciences; Kurdistan University of Medical Sciences
- Ghobad Moradi🇮🇷Kurdistan University of Medical Sciences
- Bushra Zareei🇮🇷Kurdistan University of Medical Sciences
- Mohammad Aziz Rasouli🇮🇷 · autor de correspondenciaKurdistan University of Medical Sciences
- Bahram Nikkhoo🇮🇷Kurdistan University of Medical Sciences
- Daem Roshani🇮🇷Kurdistan University of Medical Sciences
- Ebrahim Ghaderi🇮🇷Kurdistan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is a controversy about the association between vitamin D and cardiovascular diseases (CVDs). The effect of serum 25-OH-vitD on the risk of CVDs was evaluated.
Methods
Major electronic databases including Scopus, Science Direct, and PubMed were searched. All prospective cohort studies on the relationship between vitamin D status and CVDs conducted between April 2000 and September 2017 were included, regardless language. The study participants were evaluated regardless of their age, sex, and ethnicity. The Newcastle-Ottawa Scale was used to assess the quality of the studies. Two investigators independently selected the studies and extracted the data. The designated effects were risk ratio (RR) and hazard ratio (HR). The random effects model was used to combine the results.
Results
A meta-analysis of 25 studies with 10,099 cases of CVDs was performed. In general, a decrease in the level of vitamin D was associated with a higher relative risk of CVDs (incidence-mortality combined) (RR = 1.44, 95% CI: 1.24-1.69). This accounts for 54% of CVDs mortality rate (RR = 1.54, 95% CI: 1.29-1.84(. However, no significant relationship was observed between the vitamin D status and incidence of CVDs (RR = 1.18, 95% CI: 1-1.39). In general, low serum vitamin D level increased the risk of CVD by 44% (RR = 1.44, 95% CI: 1.24-1.69). It also increased the risk of CVD mortality (RR = 1.54, 95% CI: 1.29-1.84) and incidence rates (RR = 1.18, 95% CI: 1-1.39).
Conclusions
The findings showed that vitamin D deficiency increases the CVDs mortality rate. Due to the limited number of studies on patients of the both genders, further research is suggested to separately evaluate the effect of vitamin D status on CVD in men and women.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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