Processed Meat Intake and Risk of Chronic Obstructive Pulmonary Disease among Middle-aged Women
Varraso R, Dumas O, Boggs KM, Willett WC, Speizer FE, Camargo CA
EClinicalMedicine · 16 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Brigham and Women's Hospital
- Gobierno
- National Institutes of Health
- Gobierno
- Centers for Disease Control and Prevention
- Subvenciones
- Centers for Disease Control and Prevention (R01 OH-10359); National Institutes of Health (UM1 CA 176726)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-08-03 · EClinicalMedicine · vol. 14 · págs. 88–95
- Editorial
- Elsevier BV
- Citado
- 28 citas · más que el 86% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Chronic Obstructive Pulmonary Disease (COPD) Research · Nutritional Studies and Diet · Cardiovascular Health and Risk Factors
- Palabras clave
- Medicine, COPD, Hazard ratio, Proportional hazards model, Pulmonary disease, Processed meat, Red meat, Internal medicine, Lower risk, Environmental health, Confidence interval, Food science
6 autores
- Raphaëlle Varraso🇫🇷 · autor de correspondenciaInserm; Université de Versailles Saint-Quentin-en-Yvelines; Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
- Orianne Dumas🇫🇷Inserm; Université de Versailles Saint-Quentin-en-Yvelines; Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
- Krislyn M. Boggs🇺🇸Brigham and Women's Hospital; Harvard University; Massachusetts General Hospital
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Frank E. Speizer🇺🇸Brigham and Women's Hospital; Harvard University
- Carlos A. Camargo🇺🇸Brigham and Women's Hospital; Harvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Processed meat intake may increase the risk of chronic obstructive pulmonary disease (COPD). However, the magnitude of this association may depend on smoking and unhealthy diet. Our aims were to determine whether processed meat intake increased the risk of COPD among middle-aged women, and to estimate the combined impact of high processed meat intake, smoking and unhealthy diet on the risk of COPD.
Methods
Analyses included 87,032 registered nurses from the Nurses' Health Study II (baseline mean age 36.8 years). Over 2,296,894 person-years (1991-2017), we documented 634 incident cases of COPD. Cumulative average of processed meat intake (every 4 years) was divided into never/almost never, < 1 or ≥ 1 servings/week. A score was created to study the impact of 3-risk lifestyle factors.
Findings
In multivariable-adjusted Cox proportional hazards models, after careful adjustment for smoking and unhealthy diet, we observed a positive association between processed meat intake and the risk of COPD: Hazard Ratio (HR, 95%CI) for ≥ 1 servings/week vs. never/almost never = 1.29 (1.00-1.65). In analyses stratified according to smoking or unhealthy diet, processed meat intake was associated with increased risk of COPD only among ever smokers (HR 1.37 [1.01-1.86]), and among women with unhealthy diet (HR 1.39 [1.04-1.85]). The multivariable-adjusted HR for COPD in participants with all 3 high-risk lifestyle factors compared with none was 6.32 (3.67-10.87).
Interpretation
Processed meat intake was associated with elevated risk of developing COPD in middle-aged women, especially in presence of other high-risk lifestyle factors (smoking, unhealthy diet).
Fundings
US CDC and NIH.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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