Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
Ruggiero C, Baroni M, Bini V, Brozzetti A, Parretti L, Zengarini E, Lapenna M, Antinolfi P, Falorni A, Mecocci P, Boccardi V
Nutrients · 18 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-11-15 · Nutrients · vol. 11 · número 11 · pág. 2778
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 23 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Pharmacological Effects and Toxicity Studies
- Palabras clave
- Cholecalciferol, Calcifediol, Medicine, Vitamin D and neurology, Internal medicine, Parathyroid hormone, Vitamin, Endocrinology, Randomized controlled trial, Polypharmacy, vitamin D deficiency, Calcium
- MeSH
- humans, vitamin d deficiency, cholecalciferol, calcifediol, parathyroid hormone, vitamin d, c-reactive protein, hand strength, treatment outcome, polypharmacy, hospitalization, drug administration schedule, dietary supplements, aged, 80 and over, female, male, biomarkers
11 autores
- Carmelinda Ruggiero🇮🇹 · autor de correspondenciaUniversity of Perugia
- Marta Baroni🇮🇹University of Perugia
- Vittorio Bini🇮🇹University of Perugia
- Annalisa Brozzetti🇮🇹University of Perugia
- Luca Parretti🇮🇹University of Perugia
- Elisa Zengarini🇮🇹Istituto Nazionale di Riposo e Cura per Anziani
- Maria Lapenna🇮🇹University of Perugia
- Pierluigi Antinolfi🇮🇹Ospedale Santa Maria
- Alberto Falorni🇮🇹University of Perugia
- Patrizia Mecocci🇮🇹University of Perugia
- Virginia Boccardi🇮🇹University of Perugia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment. Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p p = 0.01). Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04). Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites. In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels.
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