A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction
Ng QX, Loke W, Foo NX, Tan WJ, Chan HW, Lim DY, Yeo WS
Phytotherapy research : PTR · 43 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-11-19 · Phytother Res · vol. 34 · número 3 · págs. 583–590
- Editorial
- Wiley
- Citado
- 77 citas · más que el 92% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection
- Palabras clave
- Withania somnifera, Dementia, Medicine, Schizoaffective disorder, Population, Cognition, Cognitive decline, Psychiatry, Randomized controlled trial, Schizophrenia (object-oriented programming), Montreal Cognitive Assessment, Systematic review, MEDLINE, Psychosis, Alternative medicine, Cognitive impairment, Surgery, Internal medicine, Disease, Biology, Pathology
- MeSH
- humans, withania, dementia, plant extracts, medicine, ayurvedic, cognition, memory, aged, aged, 80 and over, randomized controlled trials as topic, cognitive dysfunction
7 autores
- Qin Xiang Ng🇸🇬 · autor de correspondenciaInstitute of Mental Health; MOH Holdings
- Wayren Loke🇸🇬MOH Holdings
- Nadine Xinhui Foo🇸🇬MOH Holdings
- Weng Jun Tan🇸🇬Institute of Mental Health; MOH Holdings
- Hwei Wuen Chan🇸🇬National University of Singapore; National University Hospital; National University Health System
- Donovan Yutong Lim🇸🇬National University of Singapore; Institute of Mental Health
- Wee Song Yeo🇸🇬National University of Singapore; National University Hospital; National University Health System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Many developed countries are experiencing a rapidly "greying" population, and cognitive decline is common in the elderly. There is no cure for dementia, and pharmacotherapy options to treat cognitive dysfunction provide limited symptomatic improvements. Withania somnifera (Ashwagandha), a popular herb highly valued in Ayurvedic medicine, has often been used to aid memory and cognition. This systematic review thus aimed to evaluate the clinical evidence base and investigate the potential role of W. somnifera in managing cognitive dysfunction. Using the following keywords [withania somnifera OR indian ginseng OR Ashwagandha OR winter cherry] AND [brain OR cognit* OR mental OR dementia OR memory], a comprehensive search of PubMed, EMBASE, Medline, PsycINFO and Clinicaltrials.gov databases found five clinical studies that met the study's eligibility criteria. Overall, there is some early clinical evidence, in the form of randomized, placebo-controlled, double-blind trials, to support the cognitive benefits of W. somnifera supplementation. However, a rather heterogeneous study population was sampled, including older adults with mild cognitive impairment and adults with schizophrenia, schizoaffective disorder, or bipolar disorder. In most instances, W. somnifera extract improved performance on cognitive tasks, executive function, attention, and reaction time. It also appears to be well tolerated, with good adherence and minimal side effects.
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