Financiado en parte por California Strawberry Commission
The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro
Rutledge GA, Fisher DR, Miller MG, Kelly ME, Bielinski DF, Shukitt-Hale B
Food & function · 30 citas
Etiquetas de revisión
Financiado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- California Strawberry Commission
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (T32-AG-000029); National Institute on Aging (R01 AG029411); National Institute on Aging (P60 AG011268); National Institutes of Health (T32 AG00002941)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2019-01-01 · Food Funct · vol. 10 · número 12 · págs. 7707–7713
- Editorial
- Royal Society of Chemistry
- Citado
- 46 citas · más que el 88% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Natural Antidiabetic Agents Studies · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Polyphenol, Antioxidant, In vitro, Berry, Chemistry, Anti-inflammatory, Antioxidant capacity, Oxidative stress, Food science, Biology, Biochemistry, Botany, Pharmacology
- MeSH
- microglia, animals, humans, rats, fragaria, fruit, nitric oxide, tumor necrosis factor-alpha, double-blind method, oxidative stress, aging, postprandial period, aged, middle aged, female, male, nitric oxide synthase type ii, blueberry plants
6 autores
- Grant A. Rutledge🇺🇸Tufts University; Agricultural Research Service
- Derek R. Fisher🇺🇸Tufts University; Agricultural Research Service
- Marshall G. Miller🇺🇸Tufts University; Agricultural Research Service
- Megan E. Kelly🇺🇸Tufts University; Agricultural Research Service
- Donna F. Bielinski🇺🇸Tufts University; Agricultural Research Service
- Barbara Shukitt‐Hale🇺🇸 · autor de correspondenciaTufts University; Agricultural Research Service
Resumen
El texto original del estudio, en el idioma en que se publicó.
Berry fruits contain a variety of bioactive polyphenolic compounds that exhibit potent antioxidant and anti-inflammatory activities. We have shown that consumption of freeze-dried whole berry powder, equivalent to 1 cup per day of blueberry (BB) or 2 cups per day of strawberry (SB), can differentially improve some aspects of cognition in healthy, older adults, compared to placebo-supplemented controls. We investigated whether fasting and postprandial serum from BB- or SB-supplemented older adults (60-75 years), taken at baseline or after 45 or 90 days of supplementation, would reduce the production of inflammatory and oxidative stress markers compared to serum from a placebo group, in LPS-stressed HAPI rat microglial cells, in vitro. Serum from both BB- and SB-supplemented participants reduced nitrite production, iNOS and COX-2 expression, and TNF-alpha release relative to serum from placebo controls (p < 0.05). Protection was greatest with serum from the 90-day time-point, suggesting that ongoing supplementation may provide the most health benefits. Serum was protective in both fasted and postprandial conditions, indicating that the effects are not only acute and that the meal did not challenge subjects' ability to regulate oxidative and inflammatory stress. These results suggest that berry metabolites, present in the circulating blood following ingestion, may be mediating the anti-inflammatory effects of dietary berry fruit.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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