Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis
Zhao B, Deng H, Li B, Chen L, Zou F, Hu L, Wei Y, Zhang W
Diabetes/metabolism research and reviews · 24 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81560345)
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-11-23 · Diabetes Metab Res Rev · vol. 36 · número 3 · pág. e3243
- Editorial
- Wiley
- Citado
- 34 citas · más que el 63% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Parathyroid Disorders and Treatments
- Palabras clave
- Type 2 diabetes, Medicine, Diabetes mellitus, Magnesium, Internal medicine, Endocrinology, Chemistry
- MeSH
- humans, diabetes mellitus, type 2, magnesium, blood glucose, glucose tolerance test, fasting, dietary supplements
8 autores
- Binghao Zhao🇨🇳Nanchang University; Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital; Second Affiliated Hospital of Nanchang University
- Huan Deng🇨🇳Nanchang University; First Affiliated Hospital of Jiangxi Medical College; Second Affiliated Hospital of Nanchang University
- Bo Li🇨🇳Nanchang University; First Affiliated Hospital of Jiangxi Medical College; Second Affiliated Hospital of Nanchang University
- Chen Lian🇨🇳Nanchang University; First Affiliated Hospital of Jiangxi Medical College; Second Affiliated Hospital of Nanchang University
- Fang Zou🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Lei Hu🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Yiping Wei🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Wenxiong Zhang🇨🇳 · autor de correspondenciaNanchang University; Second Affiliated Hospital of Nanchang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Prevention of type 2 diabetes (T2D) with diet or diet supplementation is challenging. This article aims to draw conclusive associations between magnesium intake and T2D incidence and evaluate the effect of magnesium supplementation on glucose metabolism. Databases were searched for related articles from inception to May 15, 2019. Prospective cohort studies investigating the relevant relationship as well as randomized controlled trials (RCTs) assessing the effect of magnesium supplementation were eligible. We conducted trial sequential analysis (TSA) to prove the sufficiency of the current evidence. Twenty-six publications involving 35 cohorts were included in the analysis. Compared to the lowest magnesium intake, the highest level was associated with a 22% lower risk for T2D; the risk was reduced by 6% for each 100 mg increment in daily magnesium intake. Additional analysis of 26 RCTs (1168 participants) was performed, revealing that magnesium supplementation significantly reduced the fasting plasma glucose (FPG) level (SMD, -0.32 [95% CI, -0.59 to -0.05], 2-hour oral glucose tolerance test (2-h OGTT) result (SMD, -0.30 [-0.58 to -0.02]), fasting insulin level (SMD, -0.17 [-0.30 to -0.04]), homeostatic model assessment-insulin resistance (HOMA-IR) score (SMD, -0.41 [-0.71 to -0.11]), triglyceride (TG) level, systolic blood pressure (SBP) and diastolic blood pressure (DBP). TSA showed an inverse association, with most benefits of magnesium supplementation on glucose metabolism being stable. In conclusion, magnesium intake has an inverse dose-response association with T2D incidence, and supplementation appears to be advisable in terms of glucose parameters in T2D/high-risk individuals.
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