The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation
Carpi S, Scoditti E, Massaro M, Polini B, Manera C, Digiacomo M, Esposito Salsano J, Poli G, Tuccinardi T, Doccini S, Santorelli FM, Carluccio MA, Macchia M, Wabitsch M, De Caterina R, Nieri P
Nutrients · 85 citas
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- Financiación independiente
- Universidad u hospital
- This work was partially supported by funds from the University of Pisa.
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-11-21 · Nutrients · vol. 11 · número 12 · pág. 2855
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 108 citas · más que el 99% de estudios similares · 11.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 127 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Atherosclerosis and Cardiovascular Diseases · Natural product bioactivities and synthesis
- Palabras clave
- Inflammation, Adipocyte, Adipose tissue, Tumor necrosis factor alpha, Angiogenesis, Chemistry, NF-κB, Endocrinology, Internal medicine, Biology, Biochemistry, Medicine
- MeSH
- cells, cultured, adipocytes, humans, inflammation, aldehydes, phenols, nf-kappa b, micrornas, signal transduction, gene expression regulation, exosomes, cyclopentane monoterpenes
16 autores
- Sara Carpi🇮🇹 · autor de correspondenciaUniversity of Pisa
- Egeria Scoditti🇮🇹Istituto di Fisiologia Clinica; National Research Council
- Marika Massaro🇮🇹Istituto di Fisiologia Clinica; National Research Council
- Beatrice Polini🇮🇹University of Pisa
- Clementina Manera🇮🇹University of Pisa
- Maria Digiacomo🇮🇹University of Pisa
- Jasmine Esposito Salsano🇮🇹University of Siena; University of Pisa
- Giulio Poli🇮🇹University of Pisa
- Tiziano Tuccinardi🇮🇹University of Pisa
- Stefano Doccini🇮🇹Fondazione Stella Maris
- Filippo Maria Santorelli🇮🇹Fondazione Stella Maris
- Maria Annunziata Carluccio🇮🇹Istituto di Fisiologia Clinica; National Research Council
- Marco Macchia🇮🇹University of Pisa
- Martin Wabitsch🇩🇪Universität Ulm
- Raffaele De Caterina
- Paola Nieri🇮🇹University of Pisa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Inflammation of the adipose tissue plays an important role in the development of several chronic diseases associated with obesity. Polyphenols of extra virgin olive oil (EVOO), such as the secoiridoids oleocanthal (OC) and oleacein (OA), have many nutraceutical proprieties. However, their roles in obesity-associated adipocyte inflammation, the NF-κB pathway and related sub-networks have not been fully elucidated. Here, we investigated impact of OC and OA on the activation of NF-κB and the expression of molecules associated with inflammatory and dysmetabolic responses. To this aim, fully differentiated Simpson-Golabi-Behmel syndrome (SGBS) adipocytes were pre-treated with OC or OA before stimulation with TNF-α. EVOO polyphenols significantly reduced the expression of genes implicated in adipocyte inflammation (IL-1β, COX-2), angiogenesis (VEGF/KDR, MMP-2), oxidative stress (NADPH oxidase), antioxidant enzymes (SOD and GPX), leukocytes chemotaxis and infiltration (MCP-1, CXCL-10, MCS-F), and improved the expression of the anti-inflammatory/metabolic effector PPARγ. Accordingly, miR-155-5p, miR-34a-5p and let-7c-5p, tightly connected with the NF-κB pathway, were deregulated by TNF-α in both cells and exosomes. The miRNA modulation and NF-κB activation by TNF-α was significantly counteracted by EVOO polyphenols. Computational studies suggested a potential direct interaction between OC and NF-κB at the basis of its activity. This study demonstrates that OC and OA counteract adipocyte inflammation attenuating NF-κB activation. Therefore, these compounds could be novel dietary tools for the prevention of inflammatory diseases associated with obesity.
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