Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial
Parvaresh A, Razavi R, Abbasi B, Yaghoobloo K, Hassanzadeh A, Mohammadifard N, Safavi SM, Hadi A, Clark CCT
Complementary therapies in medicine · 82 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-08-28 · Complement Ther Med · vol. 47 · pág. 102187
- Editorial
- Elsevier BV
- Citado
- 105 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- metabolic syndrome, alternate-day fasting, caloric restriction, weight loss, waist circumference, systolic blood pressure, fasting blood glucose, insulin resistance, HOMA-IR, lipid profile, dietary adherence
- MeSH
- humans, body weight, caloric restriction, fasting, adult, middle aged, female, male, waist circumference, vital signs, biomarkers, metabolic syndrome
9 autores
- Arefe Parvaresh🇮🇷Isfahan University of Medical Sciences
- Roghaye Razavi🇮🇷Isfahan University of Medical Sciences
- Behnood Abbasi🇮🇷Islamic Azad University, Tehran; Islamic Azad University, Science and Research Branch
- Khadijeh Yaghoobloo🇮🇷Isfahan University of Medical Sciences
- Akbar Hassanzadeh🇮🇷Isfahan University of Medical Sciences
- Noushin Mohammadifard🇮🇷Isfahan University of Medical Sciences
- Sayyed Morteza Safavi🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
- Amir Hadi
- Cain C. T. Clark🇬🇧Coventry University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome.
Design
This randomized clinical trial was conducted on 70 participants diagnosed with metabolic syndrome.
Setting
Patients were randomly allocated into 2 groups to follow either calorie restriction or a modified alternate-day fasting diet for 8 weeks. Diets was prescribed by dietitians and specialized for each participant. Anthropometric parameters, blood pressure, fasting plasma glucose, fasting insulin, HOMA-IR and lipid profile were measured at baseline and after trial conclusion.
Results
69, out of 70, participants completed the study and were included in the final analysis. The results showed that, compared with calorie restriction, following the modified alternate-day fasting diet significantly reduced body weight (P = 0.003), waist circumference (P = 0.026), systolic blood pressure (P = 0.029) and fasting plasma glucose (P = 0.009). However, no significant difference was observed between the 2 groups in triglyceride (P = 0.614), total cholesterol (P = 0.759), LDL-C (P = 0.289), HDL-C (P = 0.909), diastolic blood pressure (P = 0.262), HOMA- IR (P = 0.425) and fasting insulin concentrations (P = 0.496). In addition, the participants did not report any complaint due to difficulties with diet adherence when following calorie restriction or modified alternate-day fasting diet.
Conclusions
the present study suggests that modified alternate-day fasting diet may be a more effective option in managing body weight, waist circumference, systolic blood pressure, and fasting plasma glucose, compared with common calorie restriction. Further studies are needed to confirm the veracity of our results.
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