Effect of Mediterranean Diet Enriched in High Quality Extra Virgin Olive Oil on Oxidative Stress, Inflammation and Gut Microbiota in Obese and Normal Weight Adult Subjects
Luisi MLE, Lucarini L, Biffi B, Rafanelli E, Pietramellara G, Durante M, Vidali S, Provensi G, Madiai S, Gheri CF, Masini E, Ceccherini MT
Frontiers in pharmacology · 88 citas
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- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
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- Resultado principal
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- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Ente Cassa di Risparmio di Firenze
- Gobierno
- Regione Toscana
- Organización sin fines de lucro
- Fondazione Cassa di Risparmio di Firenze
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-11-14 · Front Pharmacol · vol. 10 · pág. 1366
- Editorial
- Frontiers Media
- Citado
- 116 citas · más que el 99% de estudios similares · 11.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Edible Oils Quality and Analysis
- Palabras clave
- Oxidative stress, Mediterranean diet, Gut flora, Olive oil, Inflammation, Obesity, Food science, Metabolic syndrome, Biology, Oxidative phosphorylation, Mediterranean climate, Physiology, Medicine, Endocrinology, Internal medicine, Immunology, Biochemistry, Ecology
12 autores
- Maria Luisi🇮🇹Don Carlo Gnocchi Foundation
- Laura Lucarini🇮🇹 · autor de correspondenciaUniversity of Florence
- Barbara Biffi🇮🇹Don Carlo Gnocchi Foundation
- Elena Rafanelli🇮🇹Don Carlo Gnocchi Foundation
- Giacomo Pietramellara🇮🇹University of Florence
- Mariaconcetta Durante🇮🇹University of Florence
- Sofia Vidali🇮🇹Policlinico Tor Vergata
- Gustavo Provensi🇮🇹University of Florence
- Sara Madiai🇮🇹Don Carlo Gnocchi Foundation
- Chiara Francesca Gheri🇮🇹Don Carlo Gnocchi Foundation
- Emanuela Masini🇮🇹University of Florence
- Maria Teresa Ceccherini🇮🇹University of Florence
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction: The Mediterranean Diet (MD) is useful in the prevention of overweight, obesity and metabolic disease. High Quality-Extra Virgin Olive Oil (HQ-EVOO), an essential component of this diet, exerts protective effects against chronic diseases. Gut Microbiota (GM), recognized as a key factor in driving metabolic activities, is involved in the regulation of host immunity. Lactic Acid Bacteria (LAB) and their probio-active cellular substances produce beneficial effects in the gastrointestinal tract. Materials and Methods: Eighteen overweight/obese subjects (cases, BMI ≥25 kg/m2) and 18 normal weight controls (BMI 18.5-24.9 kg/m2) were fed with MD enriched with 40 g/die HQ-EVOO for three months. Feces and blood samples were collected at time 0 (T0) and after three months (T1) for LAB composition, oxidative stress, metabolic and inflammation parameter determinations. Results: Myeloperoxidase and 8-hydroxy-2-deoxyguanosine, markers of inflammation and oxidative stress, were significantly decreased after MD rich in HQ-EVOO both in controls and in cases. Proinflammatory cytokines levels were significantly decreased in cases in comparison to controls, while IL-10 and adiponectin were significantly increased in cases. LAB's rpoB copies/ng of DNA increased 55.6 folds in cases compared to their baseline after MD rich in HQ-EVOO. MD rich in HQ-EVOO increased adiponectin and IL-10 concentration in overweight/obese subjects and decreased oxidative stress and inflammation parameters and at the same time, increased LAB number in GM. Discussion: Our results indicate that MD rich in HQ-EVOO induces an increase of LAB in GM and could have a potential role in the prevention of inflammation. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03441802.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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