Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis
Pellegrini M, Cioffi I, Evangelista A, Ponzo V, Goitre I, Ciccone G, Ghigo E, Bo S
Reviews in endocrine & metabolic disorders · 138 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Education, University and Research of Italy
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-12-06 · Rev Endocr Metab Disord · vol. 21 · número 1 · págs. 17–33
- Editorial
- Springer Science+Business Media
- Citado
- 167 citas · más que el 93% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Regulation of Appetite and Obesity
- Palabras clave
- time-restricted feeding, meal timing, weight loss, obesity, fasting blood glucose, cardiometabolic risk, fat-free mass, Ramadan fasting, fasting duration
- MeSH
- humans, obesity, body weight, weight loss, blood glucose, fasting, adult, aged, middle aged, female, male, randomized controlled trials as topic, young adult, observational studies as topic
8 autores
- Marianna Pellegrini🇮🇹University of Turin
- Iolanda Cioffi🇮🇹Federico II University Hospital
- Andrea Evangelista🇮🇹Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
- Valentina Ponzo🇮🇹University of Turin
- Ilaria Goitre🇮🇹University of Turin
- Giovannino Ciccone🇮🇹Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
- Ezio Ghigo🇮🇹University of Turin
- Simona Bo🇮🇹 · autor de correspondenciaUniversity of Turin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Restriction in meal timing has emerged as a promising dietary approach for the management of obesity and dysmetabolic diseases. The present systematic review and meta-analysis summarized the most recent evidence on the effect of time-restricted feeding (TRF) on weight-loss and cardiometabolic variables in comparison with unrestricted-time regimens. Studies involving TRF regimen were systematically searched up to January 2019. Effect size was expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). A total of 11 studies, 5 randomized controlled trials and 6 observational, were included. All selected studies had a control group without time restriction; hours of fasting ranged from 12-h until 20-h and study duration from 4 to 8-weeks. Most studies involved the Ramadan fasting. TRF determined a greater weight-loss than control regimens (11 studies, n = 485 subjects) (WMD: -1.07 kg, 95%CI: -1.74 to -0.40; p = 0.002; I2 = 56.2%), unrelated to study design. The subgroup analysis showed an inverse association between TRF and fat free mass in observational studies (WMD: -1.33 kg, 95%CI: -2.55 to -0.11; p = 0.03; I2 = 0%). An overall significant reduction in fasting glucose concentrations was observed with TRF regimens (7 studies, n = 363 subjects) (WMD: -1.71 mg/dL, 95%CI: -3.20 to -0.21; p = 0.03; I2 = 0%), above all in trials (WMD:-2.45 mg/dL, 95%CI: -4.72 to -0.17; p = 0.03; I2 = 0%). No between-group differences in the other variables were found. TRF regimens achieved a superior effect in promoting weight-loss and reducing fasting glucose compared to approaches with unrestricted time in meal consumption. However, long-term and well-designed trials are needed to draw definitive conclusions.
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