Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial
Noormandi A, Khalili H, Mohammadi M, Abdollahi A
European journal of clinical pharmacology · 28 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-12-09 · Eur J Clin Pharmacol · vol. 76 · número 2 · págs. 175–184
- Editorial
- Springer Science+Business Media
- Citado
- 42 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sepsis Diagnosis and Treatment · Magnesium in Health and Disease · Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Palabras clave
- magnesium supplementation, magnesium sulfate, lactate clearance, severe sepsis, critically ill patients, serum magnesium, sepsis mortality, ICU length of stay, intravenous magnesium
- MeSH
- humans, sepsis, critical illness, magnesium sulfate, lactic acid, treatment outcome, length of stay, adult, middle aged, intensive care units, female, male, administration, intravenous
4 autores
- Afsaneh Noormandi🇮🇷Tehran University of Medical Sciences
- Hossein Khalili🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
- Mostafa Mohammadi🇮🇷Imam Khomeini Hospital; Tehran University of Medical Sciences
- Alireza Abdollahi🇮🇷Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis.
Methods
Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (n = 30) or placebo (n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study.
Results
Mean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01).
Conclusions
Magnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes.
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