Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by 31P Magnetic Resonance Spectroscopy, Than With Serum Magnesium
Cameron D, Welch AA, Adelnia F, Bergeron CM, Reiter DA, Dominguez LJ, Brennan NA, Fishbein KW, Spencer RG, Ferrucci L
Frontiers in physiology · 23 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of East Anglia
- Gobierno
- National Institutes of Health
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-11-26 · Front Physiol · vol. 10 · pág. 1454
- Editorial
- Frontiers Media
- Citado
- 29 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Parathyroid Disorders and Treatments
- Palabras clave
- Magnesium, Intracellular, Magnetic resonance imaging, Nuclear magnetic resonance, Resonance (particle physics), Function (biology), Nuclear magnetic resonance spectroscopy, Chemistry, Internal medicine, Medicine, Endocrinology, Biophysics, Biochemistry, Biology, Physics, Cell biology, Atomic physics, Radiology
10 autores
- Donnie Cameron🇬🇧🇺🇸 · autor de correspondenciaUniversity of East Anglia; National Institutes of Health; Institute on Aging; National Institute on Aging
- Ailsa A. Welch🇬🇧University of East Anglia
- Fatemeh Adelnia🇺🇸National Institutes of Health; Institute on Aging; National Institute on Aging
- Christopher M. Bergeron🇺🇸National Institutes of Health; Institute on Aging; National Institute on Aging
- David A. Reiter🇺🇸Emory University
- Ligia Juliana Dominguez🇮🇹University of Palermo
- Nicholas A. Brennan🇺🇸National Institutes of Health; Institute on Aging; National Institute on Aging
- Kenneth W. Fishbein🇺🇸National Institutes of Health; Institute on Aging; National Institute on Aging
- Richard G. S. Spencer🇺🇸National Institutes of Health; Institute on Aging; National Institute on Aging
- Luigi Ferrucci🇺🇸 · autor de correspondenciaNational Institutes of Health; Institute on Aging; National Institute on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Total serum magnesium is a common clinical measurement for assessing magnesium status; however, magnesium in blood represents less than 1% of the body's total magnesium content. We measured intramuscular ionized magnesium by phosphorus magnetic resonance spectroscopy (31P-MRS) and tested the hypothesis that this measure better correlates with skeletal muscle function and captures more closely the effect of aging than the traditional measure of total serum magnesium. Data were collected from 441 participants (age 24-98 years) in the Baltimore Longitudinal Study of Aging (BLSA), a study of normative aging that encompasses a broad age range. Results showed that intramuscular ionized magnesium was negatively associated with age (β = -0.29, p R 2 = 0.08) and positively associated with knee-extension strength (β = 0.31, p R 2 = 0.1 in women; and β = 0.2, p = 0.003, and R 2 = 0.04 in men), while total serum magnesium showed no association with age or strength (p = 0.27 and 0.1, respectively). Intramuscular ionized magnesium was significantly lower in women that in men (p 31P-MRS is a better clinical measure of magnesium status than total serum magnesium, and could be measured when muscle weakness of unidentified etiology is detected. It may also be used to monitor the effectiveness of oral magnesium interventions, including supplementation.
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