Association of Dietary Magnesium Intake with Fatal Coronary Heart Disease and Sudden Cardiac Death
Li J, Hovey KM, Andrews CA, Quddus A, Allison MA, Van Horn L, Martin LW, Salmoirago-Blotcher E, Song Y, Manson JE, Albert CM, Lu B, Eaton CB
Journal of women's health (2002) · 6 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HHSN268201600018C); National Heart, Lung, and Blood Institute (HHSN268201600004C); National Heart, Lung, and Blood Institute (HHSN268201600001C); National Heart, Lung, and Blood Institute (R01HL091069); National Heart, Lung, and Blood Institute (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN268201600002C)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-12-12 · J Womens Health (Larchmt) · vol. 29 · número 1 · págs. 7–12
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 10 citas · más que el 66% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Quartile, Hazard ratio, Sudden cardiac death, Confidence interval, Internal medicine, Confounding, Cause of death, Population, Cardiology, Disease, Environmental health
- MeSH
- humans, death, sudden, cardiac, coronary disease, magnesium, proportional hazards models, risk factors, cohort studies, prospective studies, risk reduction behavior, nutritional status, postmenopause, aged, middle aged, united states, female, surveys and questionnaires
13 autores
- Jason Li🇺🇸Brown University; Memorial Hospital of Rhode Island
- Kathleen M. O'Reilly Hovey🇺🇸University at Buffalo, State University of New York
- Chris Andrews🇺🇸University of Michigan
- Abdullah Quddus🇺🇸St. Luke's University Health Network
- Matthew Allison🇺🇸University of California San Diego
- Linda Van Horn🇺🇸Northwestern University
- Lisa Warsinger Martin🇺🇸George Washington University
- Elena Salmoirago‐Blotcher🇺🇸Brown University; Miriam Hospital
- Yiqing Song🇺🇸Indiana University – Purdue University Indianapolis
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Christine M. Albert🇺🇸Brigham and Women's Hospital; Harvard University
- Bing Lü🇺🇸Brigham and Women's Hospital; Harvard University
- Charles B. Eaton🇺🇸 · autor de correspondenciaBrown University; Memorial Hospital of Rhode Island
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Postmenopausal women represent the highest population-based burden of cardiovascular disease, including sudden cardiac death (SCD). Our understanding of the etiology and risk factors contributing to fatal coronary heart disease (CHD) and SCD, particularly among women, is limited. This study examines the association between dietary magnesium intake and fatal CHD and SCD. Materials and Methods: We examined 153,569 postmenopausal women who participated in the Women's Health Initiative recruited between 1993 and 1998. Magnesium intake at baseline was assessed using a validated food frequency questionnaire, adjusting for energy via the residual method. Fatal CHD and SCD were identified over an average follow-up of 10.5 years. Results: For every standard deviation increase in magnesium intake, there was statistically significant risk reduction, after adjustment for confounders, of 7% for fatal CHD (hazard ratio [HR] 0.93, 95% confidence interval [CI] 0.89-0.97), and 18% risk reduction for SCD (HR 0.82, 95% CI 0.58-1.15) the latter of which did not reach statistical significance. In age-adjusted quartile analysis, women with the lowest magnesium intake (189 mg/day) had the greatest risk for fatal CHD (HR 1.54, 95% CI 1.40-1.69) and SCD (HR 1.70, 95% CI 0.94-3.07). This association was attenuated in the fully adjusted model, with HRs of 1.19 (95% CI 1.06-1.34) for CHD and 1.24 (95% CI 0.58-2.65) for SCD for the lowest quartile of magnesium intake. Conclusions: This study provides evidence of a potential inverse association between dietary magnesium and fatal CHD and a trend of magnesium with SCD in postmenopausal women. Future studies should confirm this association and consider clinical trials to test whether magnesium supplementation could reduce fatal CHD in high-risk individuals.
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