Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy
Chang YW, Park YM, Oh CH, Oh SJ, Cho JH, Kim JW, Jang JY
The Korean journal of internal medicine · 23 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Kyung Hee University
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-12-13 · Korean J Intern Med · vol. 35 · número 3 · págs. 574–581
- Editorial
- Korean Association of Internal Medicine
- Citado
- 31 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Helicobacter pylori-related gastroenterology studies · Gastrointestinal motility and disorders · Hepatitis C virus research
- Palabras clave
- Helicobacter pylori eradication, probiotics, Saccharomyces boulardii, broccoli sprout extract, sulforaphane, clarithromycin, triple therapy, clarithromycin resistance, chronic gastritis, peptic ulcer, CYP2C19 polymorphism, antibiotic adverse events, 23S rRNA mutations
- MeSH
- humans, helicobacter pylori, brassica, helicobacter infections, amoxicillin, clarithromycin, anti-bacterial agents, drug therapy, combination, probiotics, proton pump inhibitors, republic of korea
7 autores
- Young Woon Chang🇰🇷Kyung Hee University
- Yoo Min Park🇰🇷Kyung Hee University
- Chi Hyuk Oh🇰🇷 · autor de correspondenciaKyung Hee University
- Shin Ju Oh🇰🇷Kyung Hee University
- Jun‐Hyung Cho🇰🇷Soonchunhyang University
- Jung‐Wook Kim🇰🇷Kyung Hee University
- Jae Young Jang🇰🇷Kyung Hee University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/aims
The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli sprout extract sulforaphane supplementation could increase the H. pylori eradication rate and/or reduce antibiotic-associated adverse events.
Methods
A total of 217 patients with H. pylori-positive chronic gastritis or peptic ulcer disease were recruited. Clarithromycin resistance was assessed in all patients by testing for A2142G and A2143G point mutations in H. pylori 23S rRNA using a dual-priming polymerase chain reaction (PCR) oligonucleotide. Thirty-four patients (17.3%) were clarithromycin-resistant and were excluded from the study. Finally, 183 patients with infections not resistant to clarithromycin were randomly assigned to triple therapy only (group A, n = 61), triple therapy plus probiotics (group B, n = 61), or triple therapy plus sulforaphane (group C, n = 61) groups. CYP2C19 polymorphisms were examined at position G681A of exon 5 and G636A of exon 4 by PCR with restriction fragment length polymorphism (PCR-RFLP) analysis. H. pylori eradication was assessed by 13C-urea breath test 4 weeks after treatment completion.
Results
The eradication rates were similar among the groups both in the intention- to-treat (A = 85.2%, B = 89.6%, and C = 81.6%) and per-protocol (A = 89.2%, B = 86.8%, and C = 96.3%) analyses. The frequencies of overall adverse events in the groups also did not differ (A vs. B: p = 0.574; A vs. C: p = 1.000).
Conclusion
Probiotic or sulforaphane with triple therapy for H. pylori infection neither increased the eradication rate nor reduced the occurrence of adverse events.
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