Effects of Oral Magnesium Supplementation on Vascular Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Marques BCAA, Klein MRST, da Cunha MR, de Souza Mattos S, de Paula Nogueira L, de Paula T, Corrêa FM, Oigman W, Neves MF
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 24 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-12-16 · High Blood Press Cardiovasc Prev · vol. 27 · número 1 · págs. 19–28
- Editorial
- Adis, Springer Healthcare
- Citado
- 42 citas · más que el 75% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 62 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Magnesium Alloys: Properties and Applications
- Palabras clave
- oral magnesium supplementation, vascular function, endothelial function, flow-mediated dilation, pulse wave velocity, arterial stiffness, duration of supplementation, overweight, older adults
- MeSH
- endothelium, vascular, humans, cardiovascular diseases, obesity, magnesium, body mass index, treatment outcome, administration, oral, risk factors, age factors, health status, vasodilation, time factors, dietary supplements, adult, aged, middle aged, female, male, randomized controlled trials as topic, vascular stiffness
9 autores
- Bianca Cristina Marques🇧🇷Universidade do Estado do Rio de Janeiro; Instituto Nacional de Câncer - INCA
- Márcia Regina Simas Torres Klein🇧🇷Universidade do Estado do Rio de Janeiro
- Michelle Rabello Cunha🇧🇷Universidade do Estado do Rio de Janeiro
- Samanta Souza Mattos🇧🇷Universidade do Estado do Rio de Janeiro
- Lívia de Paula Nogueira🇧🇷Universidade do Estado do Rio de Janeiro
- Tainah de Paula🇧🇷Universidade do Estado do Rio de Janeiro
- Flávia de Miranda Corrêa🇧🇷Instituto Nacional de Câncer - INCA
- Wille Oigman🇧🇷Universidade do Estado do Rio de Janeiro
- Mário Fritsch Neves🇧🇷 · autor de correspondenciaUniversidade do Estado do Rio de Janeiro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
The effects of magnesium (Mg) supplementation on vascular function have been evaluated in some randomized controlled trials (RCT) but their results are conflicting.
Aim
A systematic review and meta-analysis were conducted to summarize the effects of oral Mg supplementation on vascular function in RCT.
Methods
The databases MEDLINE (PubMed), Embase, Web of Science and Cochrane Library were accessed from inception to May 27, 2019. Intergroup differences (treatment vs. control group) related to changes in flow-mediated dilation (FMD) and pulse wave velocity (PWV), expressed as mean and standard deviation, were used to evaluate the effect of Mg supplementation on these outcomes. The results of the meta-analysis were expressed using a random-effects model. The heterogeneity between studies was evaluated using the I2 statistic.
Results
The oral supplementation of Mg had no significant effect on FMD (mean difference 2.13; 95% CI - 0.56, 4.82; p = 0.12) and PWV (mean difference - 0.54, 95% CI - 1.45, 0.36, p = 0.24). Heterogeneity for both outcomes (FMD and PWV) was high (I2 = 99%, p 2. The reduced number of RCT and the heterogeneity among them were the main limitations.
Conclusions
This meta-analysis suggest that oral Mg supplementation may improve endothelial function when conducted at least for 6 months and in unhealthy, overweight or older individuals. Registration number: PROSPERO CRD42019111462.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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