Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial
Cai H, Qin YL, Shi ZY, Chen JH, Zeng MJ, Zhou W, Chen RQ, Chen ZY
BMC gastroenterology · 154 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-12-01 · BMC Gastroenterol · vol. 19 · número 1 · pág. 219
- Editorial
- BioMed Central
- Citado
- 204 citas · más que el 99% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Enhanced Recovery After Surgery
- Palabras clave
- Medicine, Internal medicine, Fatty liver, Intermittent fasting, Body mass index, Weight loss, Endocrinology, Anthropometry, Hepatology, Body weight, Cholesterol, Animal science, Gastroenterology, Obesity, Disease, Biology
- MeSH
- humans, metabolic diseases, body weight, weight loss, cholesterol, triglycerides, fasting, risk factors, feeding behavior, hunger, body composition, energy intake, time factors, adult, female, male, adiposity, dyslipidemias, non-alcoholic fatty liver disease, outcome assessment, health care
8 autores
- Hua “Linda” Cai🇨🇳Hunan Normal University
- Yuelan Qin🇨🇳Hunan Normal University
- Zeya Shi🇨🇳Hunan Normal University
- Jinhui Chen🇨🇳Hunan Normal University
- Min-Jie Zeng🇨🇳Hunan Normal University
- Wei Zhou🇨🇳Hunan Normal University
- Ru-Qun Chen🇨🇳Hunan Normal University
- Zhiyuan Chen🇨🇳 · autor de correspondenciaHunan Normal University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Alternate-day fasting (ADF) is a novel diet therapy that may achieve reduction in body weight and improvement of dyslipidaemia, but the impact of this diet on patients with non-alcoholic fatty liver disease (NAFLD) remains unknown. The aim of this study was to evaluate the effects of ADF on the body weight and lipid profile of individuals with NAFLD.
Methods
NAFLD patients (n = 271) were randomised to the ADF group, time-restricted feeding (TRF) group, or the control group and subjected to the respective diet for 12 weeks. Anthropometric measurements (body weight, fat mass/fat-free mass) were performed, and plasma lipids were analysed enzymatically.
Results
Within 4 weeks, the body weight decreased significantly (P < 0.001) in the ADF group by 4.56 ± 0.41 kg (6.1 ± 0.5%) and the TRF group by 3.62 ± 0.65 kg (4.83 ± 0.9%) compared to the control group, and it decreased even more after 12 weeks in both groups (ADF: - 4.04 ± 0.54 kg, 5.4 ± 0.7%; TRF: - 3.25 ± 0.67 kg, 4.3 ± 0.9%). Fat mass was significantly reduced by ADF (- 3.49 ± 0.37 kg; 11 ± 1.2%) and TRF (- 2.91 ± 0.41 kg; 9.6 ± 1.3%), with ADF leading to a further reduction in fat mass after 12 weeks (- 3.48 ± 0.38 kg; 11 ± 1.2%). Total cholesterol was significantly decreased at both time points in the ADF group (- 0.91 ± 0.07 mmol/L; 18.5 ± 1.5%) compared to the control and TRF groups. Both ADF (- 0.64 ± 0.06 mmol/L; 25 ± 1.9%) and TRF (0.58 ± 0.07 mmol/L; 20 ± 1.7%) achieved a significant reduction in serum triglycerides (P < 0.001) after 12 weeks. Changes in fat free mass, HDL, LDL, fasting insulin, glucose, liver stiffness, and systolic or diastolic blood pressure did not differ between the groups.
Conclusions
ADF appears to be an effective diet therapy for individuals with NAFLD that can achieve weight loss and improvement of dyslipidaemia within a relatively short period of time (4 to 12 weeks). Potential preventive effects of ADF on cardiovascular disease need to be confirmed by future investigations.
Trial registration
ChiCTR1900024411, this trial was retrospectively registered on July 10, 2019.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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