A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effectiveness of a Food Supplement Containing Creatine and D-Ribose Combined with a Physical Exercise Program in Increasing Stress Tolerance in Patients with Ischemic Heart Disease
Derosa G, Pasqualotto S, Catena G, D'Angelo A, Maggi A, Maffioli P
Nutrients · 8 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-12-17 · Nutrients · vol. 11 · número 12 · pág. 3075
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 76% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cardiovascular and exercise physiology · Muscle metabolism and nutrition · Heart rate and cardiovascular health
- Palabras clave
- creatine, D-ribose, nutraceutical supplement, ischemic heart disease, exercise tolerance, physical exercise program, chronotropic index, thiamine, vitamin B6, stress tolerance
- MeSH
- humans, myocardial ischemia, creatine, ribose, exercise test, treatment outcome, exercise, exercise therapy, double-blind method, exercise tolerance, dietary supplements, aged, middle aged, female, male
6 autores
- Giuseppe Derosa🇮🇹 · autor de correspondenciaUniversity of Pavia; Policlinico San Matteo Fondazione
- Silvia Pasqualotto🇮🇹University of Verona
- Gabriele Catena
- Angela D’Angelo🇮🇹University of Pavia; Policlinico San Matteo Fondazione
- Antonio Maggi🇮🇹Fondazione Poliambulanza Istituto Ospedaliero
- Pamela Maffioli🇮🇹University of Pavia; Policlinico San Matteo Fondazione
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this study is to establish whether a supplement of creatine and ribose combined with a physical exercise program can improve the total work capacity during exercise in a population of patients with known ischemic heart disease. A double-blind, six-month study was designed in which 53 patients were enrolled and randomized to take either a nutraceutical composition containing creatine, D-ribose, vitamin B1, and vitamin B6 (active treatment) or the placebo. Both the nutraceutical supplement and the placebo were supplied by Giellepi S.p.A. Health Science in Lissone, Italy. After six months of study, the cardiac double product at the peak of the load, the delta double product, and the chronotropic index were higher in the active treatment group than in the placebo group. We can conclude that a supplementation with creatine, D-ribose, vitamin B1, and vitamin B6, in addition to standard therapy and a physical exercise program, seems to be helpful in improving exercise tolerance compared to the placebo in a population with cardiovascular disease. However, this needs to be further studied, given that there is no clear evidence that the double product can be used as a surrogate measure of exercise tolerance.
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