Effect of time-restricted feeding on metabolic risk and circadian rhythm associated with gut microbiome in healthy males
Zeb F, Wu X, Chen L, Fatima S, Haq IU, Chen A, Majeed F, Feng Q, Li M
The British journal of nutrition · 146 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- China Scholarship Council
- Gobierno
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-01-06 · Br J Nutr · vol. 123 · número 11 · págs. 1216–1226
- Editorial
- Cambridge University Press
- Citado
- 199 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Gut microbiota and health · Diet and metabolism studies
- Palabras clave
- Circadian rhythm, Biology, Microbiome, Gut flora, Gene, Endocrinology, Internal medicine, Genetics, Immunology, Medicine
- MeSH
- liver, humans, metabolic diseases, genetic predisposition to disease, lipids, bacterial proteins, rna, ribosomal, 16s, fasting, circadian rhythm, adult, male, young adult, healthy volunteers, biomarkers, gastrointestinal microbiome, cardiometabolic risk factors
9 autores
- Falak Zeb🇨🇳Nanjing Medical University
- Xiaoyue Wu🇨🇳Nanjing Medical University
- Lijun Chen🇨🇳Nanjing Medical University
- Sadia Fatima🇵🇰Khyber Medical University
- Ijaz-ul Haq🇨🇳Nanjing Medical University
- Aochang Chen🇨🇳Nanjing Medical University
- Fatima Arshad Majeed🇨🇳Nanjing Medical University
- Qing Feng🇨🇳 · autor de correspondenciaNanjing Medical University
- Min Li🇨🇳 · autor de correspondenciaNanjing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted feeding (TRF) confers protection against nutritional challenges that predispose obesity and metabolic risks through involvement of circadian locomotor output cycles protein kaput genes and gut microbiome, but the underlying mechanism is not clearly understood. Therefore, the present study examined the effects of TRF on metabolic markers and circadian rhythm associated with gut microbiota in healthy males. Two groups (TRF, n 56; non-TRF, n 24) of male adults were enrolled. The TRF group provided blood at pre-TRF and post-TRF, while non-TRF one time after 25 d of trial. Serum lipid and liver profiles were determined. Real time-PCR was applied for circadian and inflammatory gene expression. The 16S rRNA genes were sequenced on the Illumina Miseq v3 platform to comprehensively catalogue the composition and abundance of bacteria in stool. We showed that TRF ameliorated the serum lipid and liver profiles of the individuals. In the TRF group, gut microbial richness was significantly enhanced, with enrichment of Prevotellaceae and Bacteroideaceae. TRF enhanced circadian gene expression probably by activation of sirtuin-1, which is positively associated with gut microbiome richness. TRF could be a safe remedy for the prevention of metabolic diseases related to dyslipidaemia, as it regulates circadian rhythm associated with gut microbiome modulation.
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