CD137 negatively affects "browning" of white adipose tissue during cold exposure
Srivastava RK, Moliner A, Lee ES, Nickles E, Sim E, Liu C, Schwarz H, Ibáñez CF
The Journal of biological chemistry · 19 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Medical Research Council
- Gobierno
- MOH | National Medical Research Council
- Subvenciones
- National Medical Research Council (NMRC2016-LKUI); National Medical Research Council (NMRC2018-hJET)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-01-10 · J Biol Chem · vol. 295 · número 7 · págs. 2034–2042
- Editorial
- Elsevier BV
- Citado
- 27 citas · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 21 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Cardiovascular Disease and Adiposity
- Palabras clave
- White adipose tissue, Thermogenin, Adipose tissue, PRDM16, Thermogenesis, Adipocyte, Internal medicine, Endocrinology, Brown adipose tissue, Biology, FGF21, Cell biology, Fibroblast growth factor, Receptor, Medicine
- MeSH
- animals, mice, knockout, humans, mice, body temperature, gene expression regulation, thermogenesis, adipose tissue, brown, adipose tissue, white, cold temperature, uncoupling protein 1, adipocytes, beige, tumor necrosis factor receptor superfamily, member 9
8 autores
- Raj Kamal Srivastava🇸🇬National University of Singapore; Life Sciences Institute
- Annalena Moliner🇸🇬🇸🇪National University of Singapore; Karolinska Institutet; National Neuroscience Institute; Life Sciences Institute
- Ee Soo Lee🇸🇬National University of Singapore; Life Sciences Institute
- Emily Pauline Nickles🇸🇬National University of Singapore; Life Sciences Institute
- Eunice Weiling Sim🇸🇬National University of Singapore; Life Sciences Institute
- Chang Liu🇸🇬National University of Singapore; Life Sciences Institute
- Herbert S. Schwarz🇸🇬National University of Singapore; Life Sciences Institute
- Carlos F. Ibáñez🇸🇬🇿🇦🇸🇪 · autor de correspondenciaNational University of Singapore; Stellenbosch University; Karolinska Institutet; Life Sciences Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Prolonged cold exposure stimulates the formation of brownlike adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tissue which, together with classical brown adipose tissue, contributes to maintaining body temperature in mammals through nonshivering thermogenesis. The mechanisms that regulate the formation of these cells, alternatively called beige or brite adipocytes, are incompletely understood. Here we report that mice lacking CD137, a cell surface protein used in several studies as a marker for beige adipocytes, showed elevated levels of thermogenic markers, including UCP1, increased numbers of beige adipocyte precursors, and expanded UCP1-expressing cell clusters in inguinal white adipose tissue after chronic cold exposure. CD137 knockout mice also showed enhanced cold resistance. These results indicate that CD137 functions as a negative regulator of "browning" in white adipose tissue and call into question the use of this protein as a functional marker for beige adipocytes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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