Oral magnesium supplementation for leg cramps in pregnancy-An observational controlled trial
Araújo CAL, Lorena SB, Cavalcanti GCS, Leão GLS, Tenório GP, Alves JGB
PloS one · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Bill and Melinda Gates Foundation
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Instituto Nacional de Ciência e Tecnologia da Criosfera
- Organización sin fines de lucro
- Bill & Melinda Gates Foundation
- Subvenciones
- Instituto Nacional de Ciência e Tecnologia da Criosfera (401609-2013-8); Bill and Melinda Gates Foundation (OPP1107597); Conselho Nacional de Desenvolvimento Científico e Tecnológico (2013-8)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-01-10 · PLoS One · vol. 15 · número 1 · pág. e0227497
- Editorial
- Public Library of Science
- Citado
- 10 citas · más que el 63% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 20 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Preterm Birth and Chorioamnionitis · Pregnancy and Medication Impact
- Palabras clave
- Medicine, Placebo, Pregnancy, Muscle cramp, Randomized controlled trial, Observational study, Physical therapy, Internal medicine, Alternative medicine
- MeSH
- humans, muscle cramp, gastrointestinal diseases, citric acid, organometallic compounds, administration, oral, drug administration schedule, placebo effect, pregnancy, dietary supplements, adult, female, young adult
6 autores
- Carla Adriane Leal de Araújo🇧🇷Instituto de Medicina Integral Professor Fernando Figueira
- Suélem Barros de Lorena🇧🇷Faculdade Frassinetti do Recife; Faculdade Pernambucana de Saúde
- Guilherme Camelo de Sousa Cavalcanti🇧🇷Faculdade Frassinetti do Recife; Faculdade Pernambucana de Saúde
- Gabriel Landim de Souza Leão🇧🇷Faculdade Frassinetti do Recife; Faculdade Pernambucana de Saúde
- Geraldo Padilha Tenório🇧🇷Faculdade Frassinetti do Recife; Faculdade Pernambucana de Saúde
- João Guilherme Bezerra Alves🇧🇷 · autor de correspondenciaInstituto de Medicina Integral Professor Fernando Figueira
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oral magnesium for leg cramps treatment in pregnancy is a controversial issue according to recent Cochrane systematic review. This study aims to evaluate the efficacy of Mg++ supplementation in leg cramps treatment in pregnancy.
Methods
This observational clinical trial studied 132 pregnant women with leg cramps in the first trimester of pregnancy. At baseline, 74 (56.3%) had two leg cramps episodes per week, 28 (21.1%) three episodes, 13 (9.8%) four episodes and 9 (6.8%) five or more episodes. They were randomized 1:1 to 300 mg/day of oral Mg++ citrate (n = 66) or placebo (n = 66). The primary outcome was the frequency of leg cramps episodes per week reported by pregnant women. Secondary outcomes were the ocurrence of leg cramps and oral magnesium side effects.
Results
130 pregnant women completed the study and the two groups were comparable according to some sociodemographic and clinical characteristics. After 4 weeks of intervention it was observed a 28.4% (39/132) (CI 95%: 20.9-37.0) reduction of leg cramps in all participants and no difference between the two groups was found; reduction of 27.2% (18/66) (CI 95%: 17.0-39.6) in Mg++ group and 32.8% (21/66) (CI 95%: 21.6-45.7) in the placebo group. The OR of leg cramps was 1.3 (CI 95%: 0.6-2.9), p = 0.527, taking the placebo group as reference. Among pregnant women who remained with leg cramps the mean of leg cramps episodes per week showed no significance difference between the Mg++ and placebo groups; t-student test: p = 0.408. Four pregnant women showed gastrointestinal side effects; 2 in each group had nauseas and diarrhoea.
Conclusion
Oral magnesium supplementation during pregnancy did not reduce the ocurrence and frequency of episodes of leg cramps.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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