Effects of Supplemental Vitamin D on Bone Health Outcomes in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL)
LeBoff MS, Chou SH, Murata EM, Donlon CM, Cook NR, Mora S, Lee IM, Kotler G, Bubes V, Buring JE, Manson JE
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 94 citas
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- Office of Dietary Supplements
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- Subvenciones
- National Center for Advancing Translational Sciences (UL1TR001102); National Cancer Institute (U01CA138962); National Center for Research Resources (UL 1TR001102); National Heart, Lung, and Blood Institute (R01 HL134811); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK112940); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR060574); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR070854); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059775); National Cancer Institute (R01CA138962); National Heart, Lung, and Blood Institute (K24HL136852)
Según 20 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-01-10 · J Bone Miner Res · vol. 35 · número 5 · págs. 883–893
- Editorial
- Oxford University Press
- Citado
- 120 citas · más que el 99% de estudios similares · 10.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Palabras clave
- vitamin D3 supplementation, bone mineral density, bone health, postmenopausal women, older adults, free 25-hydroxyvitamin D, 25-hydroxyvitamin D, bone structure, cortical thickness, omega-3 fatty acids, VITAL trial, sex differences, vitamin D deficiency, fracture risk, osteoporosis prevention
- MeSH
- femur neck, humans, fatty acids, omega-3, vitamin d, absorptiometry, photon, bone density, dietary supplements, adult, netherlands, female, male, outcome assessment, health care, fibroblast growth factor-23
11 autores
- Meryl Susan LeBoff🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Sharon Hsiao-Han Chou🇺🇸Brigham and Women's Hospital
- Elle M Murata🇺🇸Brigham and Women's Hospital
- Catherine M. Donlon🇺🇸Brigham and Women's Hospital
- Nancy R. Cook🇺🇸Brigham and Women's Hospital; Harvard University
- Samia Mora🇺🇸Brigham and Women's Hospital; Harvard University
- I‐Min Lee🇺🇸Brigham and Women's Hospital; Harvard University
- Gregory Kotler🇺🇸Brigham and Women's Hospital; Harvard University
- Vadim Y. Bubes🇺🇸Brigham and Women's Hospital; Harvard University
- Julie E. Buring🇺🇸Brigham and Women's Hospital; Harvard University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although supplemental vitamin D is used to promote bone health in the general population, data from randomized controlled trials (RCTs) have been inconsistent. We determined whether daily, vitamin D3 supplementation improves bone mineral density (BMD) and/or structure. VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, placebo-controlled RCT of supplemental vitamin D3 (2000 IU/d) and/or omega-3 fatty acids (1 g/d) in 25,871 adults nationwide. This ancillary study included a subcohort of 771 participants (men ≥50 and women ≥55 years; not taking bone active medications) evaluated at baseline and at 2-year follow-up (89% retention). Total 25(OH)D levels were measured by liquid chromatography tandem mass spectrometry (Quest Diagnostics, San Juan Capistrano, CA, USA). Free 25(OH)D (FVD) levels were measured using the ELISA assay by Future Diagnostics Solutions BV (Wijchen, Netherlands). Primary endpoints were 2-year changes in areal (a) BMD at the spine, hip, and whole body determined by dual-energy X-ray absorptiometry (DXA). Secondary endpoints were 2-year changes in volumetric (v) BMD and cortical thickness at the radius and tibia assessed by peripheral quantitative computed tomography. Supplemental vitamin D3 versus placebo had no effect on 2-year changes in aBMD at the spine (0.33% versus 0.17%; p = 0.55), femoral neck (-0.27% versus -0.68%; p = 0.16), total hip (-0.76% versus -0.95%; p = 0.23), or whole body (-0.22% versus -0.15%; p = 0.60), or on measures of bone structure. Effects did not vary by sex, race/ethnicity, body mass index, or 25(OH)D levels. Among participants with baseline FVD levels below the median (3 . Whether baseline FVD levels help to identify those more likely to benefit from supplementation warrants further study. Supplemental vitamin D3 versus placebo for 2 years in general healthy adults not selected for vitamin D insufficiency did not improve BMD or structure. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.
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