Financiado en parte por Dairy Farmers of Canada, Servier
Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries
Dehghan M, Mente A, Rangarajan S, Mohan V, Lear S, Swaminathan S, Wielgosz A, Seron P, Avezum A, Lopez-Jaramillo P, Turbide G, Chifamba J, AlHabib KF, Mohammadifard N, Szuba A, Khatib R, Altuntas Y, Liu X, Iqbal R, Rosengren A, Yusuf R, Smuts M, Yusufali A, Li N, Diaz R, Yusoff K, Kaur M, Soman B, Ismail N, Gupta R, Dans A, Sheridan P, Teo K, Anand SS, Yusuf S
The American journal of clinical nutrition · 76 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Population Health Research Institute
- Grupo de la industria
- Dairy Farmers of Canada
- Gobierno
- Public Health Agency of Canada
- Gobierno
- Ontario Ministry of Health and Long-Term Care
- Organización sin fines de lucro
- Saudi Heart Association
- Gobierno
- Vetenskapsrådet
- Universidad u hospital
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
- Empresa
- Servier
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Polish Ministry of Science and Higher Education
- Universidad u hospital
- Wroclaw Medical University
- Universidad u hospital
- Hamilton Health Sciences Research Institute
Según 12 financiadores declarados.
Publicación
- Publicado
- 2019-12-30 · Am J Clin Nutr · vol. 111 · número 4 · págs. 795–803
- Editorial
- Elsevier BV
- Citado
- 104 citas · más que el 99% de estudios similares · 12.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Lipoproteins and Cardiovascular Health · Cardiovascular Health and Risk Factors
- Palabras clave
- egg consumption, dietary cholesterol, serum lipids, cardiovascular disease, all-cause mortality, cardiovascular mortality, cardiovascular events, PURE study, vascular disease, low- and middle-income countries, frailty models, cardiovascular risk factors, telmisartan, ramipril, ACE inhibitors, statins
- MeSH
- humans, cardiovascular diseases, ramipril, lipids, angiotensin-converting enzyme inhibitors, proportional hazards models, prospective studies, eggs, adult, middle aged, female, male, telmisartan
35 autores
- Mahshid Dehghan🇨🇦 · autor de correspondenciaPopulation Health Research Institute; McMaster University
- Andrew Mente🇨🇦Population Health Research Institute; McMaster University
- Sumathy Rangarajan🇨🇦Population Health Research Institute; McMaster University
- Viswanathan Mohan🇮🇳Dr. Mohan's Diabetes Specialities Centre
- Scott Alexander Lear🇨🇦Simon Fraser University
- Sumathi Swaminathan🇮🇳St. John's National Academy of Health Sciences
- Andreas T. Wielgosz🇨🇦University of Ottawa
- Pamela Serón S🇨🇱Universidad de La Frontera
- Álvaro Avezum🇧🇷Instituto Dante Pazzanese de Cardiologia
- Patricio A López-Jaramillo🇨🇴Universidad De Santander
- Ginette Turbide🇨🇦Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval
- Jephat Chifamba🇿🇼University of Zimbabwe
- Khalid F. AlHabib🇸🇦King Saud University
- Noushin Mohammadifard🇮🇷Isfahan University of Medical Sciences
- Andrzej Szuba🇵🇱Wroclaw Medical University; 4. Wojskowy Szpital Kliniczny z Polikliniką
- Rasha Khatib🇺🇸🇵🇸Advocate Health Care; Birzeit University
- Yüksel Altuntaş🇹🇷Sağlık Bilimleri Üniversitesi; Şişli Etfal Eğitim ve Araştırma Hastanesi
- Xiaoyun Liu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Romaina Iqbal🇵🇰Aga Khan University
- Annika Rosengren🇸🇪Sahlgrenska University Hospital; Region Västra Götaland; University of Gothenburg
- Rita Yusuf🇧🇩Independent University, Bangladesh
- Marius Smuts🇿🇦North-West University
- Afzalhussein Yusufali🇦🇪Dubai Health Authority
- Ning Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Rafael Díaz🇦🇷Estudios Clínicos Latinoamérica
- Khalid Yusoff🇸🇦🇲🇾King Saud University; UCSI University; Universiti Teknologi MARA
- Manmeet Kaur🇮🇳Post Graduate Institute of Medical Education and Research
- Biju Soman🇮🇳Sree Chitra Thirunal Institute for Medical Sciences and Technology; Health Action by People
- Noor Hassim Ismail🇲🇾University Kebangsaan Malaysia Medical Centre
- Rajeev Gupta🇮🇳Eternal Hospital
- Antonio Dans🇵🇭University of the Philippines Manila
- Patrick Sheridan🇨🇦Population Health Research Institute; McMaster University
- Koon Kang Teo🇨🇦Population Health Research Institute; McMaster University
- Sonia Savitri Anand🇨🇦Population Health Research Institute; McMaster University
- Salim Yusuf🇨🇦Population Health Research Institute; McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Eggs are a rich source of essential nutrients, but they are also a source of dietary cholesterol. Therefore, some guidelines recommend limiting egg consumption. However, there is contradictory evidence on the impact of eggs on diseases, largely based on studies conducted in high-income countries.
Objectives
Our aim was to assess the association of egg consumption with blood lipids, cardiovascular disease (CVD), and mortality in large global studies involving populations from low-, middle-, and high-income countries.
Methods
We studied 146,011 individuals from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Egg consumption was recorded using country-specific validated FFQs. We also studied 31,544 patients with vascular disease in 2 multinational prospective studies: ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global End Point Trial) and TRANSCEND (Telmisartan Randomized Assessment Study in ACEI Intolerant Subjects with Cardiovascular Disease). We calculated HRs using multivariable Cox frailty models with random intercepts to account for clustering by study center separately within each study.
Results
In the PURE study, we recorded 14,700 composite events (8932 deaths and 8477 CVD events). In the PURE study, after excluding those with history of CVD, higher intake of egg (≥7 egg/wk compared with <1 egg/wk intake) was not significantly associated with blood lipids, composite outcome (HR: 0.96; 95% CI: 0.89, 1.04; P-trend = 0.74), total mortality (HR: 1.04; 95% CI: 0.94, 1.15; P-trend = 0.38), or major CVD (HR: 0.92; 95% CI: 0.83, 1.01; P-trend = 0.20). Similar results were observed in ONTARGET/TRANSCEND studies for composite outcome (HR 0.97; 95% CI: 0.76, 1.25; P-trend = 0.09), total mortality (HR: 0.88; 95% CI: 0.62, 1.24; P-trend = 0.55), and major CVD (HR: 0.97; 95% CI: 0.73, 1.29; P-trend = 0.12).
Conclusions
In 3 large international prospective studies including ∼177,000 individuals, 12,701 deaths, and 13,658 CVD events from 50 countries in 6 continents, we did not find significant associations between egg intake and blood lipids, mortality, or major CVD events. The ONTARGET and TRANSCEND trials were registered at clinicaltrials.gov as NCT00153101. The PURE trial was registered at clinicaltrials.gov as NCT03225586.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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