Photobiomodulation as an adjunctive therapy for alveolar socket preservation: a preliminary study in humans
Rosero KAV, Sampaio RMF, Deboni MCZ, Corrêa L, Marques MM, Ferraz EP, da Graça Naclério-Homem M
Lasers in medical science · 23 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- No
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-01-22 · Lasers Med Sci · vol. 35 · número 8 · págs. 1711–1720
- Editorial
- Springer Science+Business Media
- Citado
- 32 citas · más que el 84% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Dental Implant Techniques and Outcomes · Periodontal Regeneration and Treatments
- Palabras clave
- low-level laser therapy, alveolar bone healing, bone remodeling, bone surface, trabecular number, connectivity density, diode laser, molar extraction, bone histology
- MeSH
- tooth socket, humans, imaging, three-dimensional, biopsy, treatment outcome, adult, aged, middle aged, female, male, lasers, semiconductor, young adult, low-level light therapy
7 autores
- Kleber Arturo Vallejo Rosero🇪🇨🇧🇷Central University of Ecuador; Universidade de São Paulo
- Rui Manuel Freire Sampaio🇧🇷Universidade de São Paulo
- Maria Cristina Zindel Deboni🇧🇷Universidade de São Paulo
- Luciana Côrrea🇧🇷Universidade de São Paulo
- Márcia Martins Marques🇧🇷Universidade Ibirapuera
- Emanuela Prado Ferraz🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Maria da Graça Naclério‐Homem🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Bone remodeling results in loss of alveolar bone height and thickness. Photobiomodulation (PBM) based on photochemical stimulation by low-intensity lasers emerges as an adjunctive therapy for alveolar socket preservation. Our study aimed to evaluate the effects of PBM therapy on alveolar bone repair. Twenty healthy patients in need of bilateral extraction of lower molars were enrolled in this split-mouth randomized and blind clinical trial. The extraction sites were randomly selected to receive either the PBM therapy with a CW GaAIAs diode laser (808 nm; 0.028 mm2; 0.1 W; 3.6 W/cm2; 89 J/cm2; 2.5 J/point) or no treatment (Control). Bone biopsies were harvested 45 days after the dental extraction and evaluated using micro-computerized tomography (μCT), morphometric, and histological analysis. Data were compared using the paired t test, and the level of significance was set at 5%. Bone surface (p = 0.029), bone surface/total volume (p = 0.028), trabecular number (p = 0.025), and connectivity density (p = 0.029) were higher at the PBM group compared with Control. The histological observations confirmed the μCT findings. PBM samples exhibited higher number of organized and connected bone trabeculae along with higher density of blood vessels than Control. Control samples displayed a dense and highly cellular connective tissue at the central area accompanied by the presence of immature bone trabeculae at the periphery. Our results indicated that the PBM therapy improved the newly bone trabeculae formation and their connectivity which increased bone surface, indicating the positive effect of the laser on alveolar human socket repair.
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