Creative music therapy to promote brain function and brain structure in preterm infants: A randomized controlled pilot study
Haslbeck FB, Jakab A, Held U, Bassler D, Bucher HU, Hagmann C
NeuroImage. Clinical · 67 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Universidad u hospital
- Universität Zürich
- Organización sin fines de lucro
- EMDO Stiftung
- Organización sin fines de lucro
- Vontobel-Stiftung
- Universidad u hospital
- Universitätsspital Zürich
- Organización sin fines de lucro
- Foundation for Research in Science and the Humanities
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-01-01 · Neuroimage Clin · vol. 25 · pág. 102171
- Editorial
- Elsevier BV
- Citado
- 136 citas · más que el 100% de estudios similares · 22.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 99 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Infant Development and Preterm Care · Neonatal and fetal brain pathology · Infant Health and Development
- Palabras clave
- Resting state fMRI, Randomized controlled trial, Music therapy, Medicine, Cognition, Brain activity and meditation, Psychology, Neuroscience, Audiology, Physical therapy, Electroencephalography, Internal medicine
- MeSH
- thalamus, cerebral cortex, nerve net, humans, music therapy, prospective studies, feasibility studies, pilot projects, infant, newborn, infant, premature, diffusion tensor imaging, infant, extremely premature, connectome
6 autores
- Friederike Barbara Haslbeck🇨🇭 · autor de correspondenciaUniversity Hospital Zurich
- András Áron Jakab🇨🇭University Children's Hospital Zurich
- Ulrike Held
- Dirk Bassler🇨🇭University Hospital Zurich
- Hans-Ulrich Bucher🇨🇭University Hospital Zurich
- Cornelia Franziska Hagmann🇨🇭University Hospital Zurich; University Children's Hospital Zurich
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cognitive and neurobehavioral problems are among the most severe adverse outcomes in very preterm infants. Such neurodevelopmental impairments may be mitigated through nonpharmacological interventions such as creative music therapy (CMT), an interactive, resource- and needs-oriented approach that provides individual social contact and musical stimulation. The aim was to test the feasibility of a study investigating the role of CMT and to measure the short- and medium-term effects of CMT on structural and functional brain connectivity with MRI. In this randomized, controlled clinical pilot feasibility trial, 82 infants were randomized to either CMT or standard care. A specially trained music therapist provided CMT via infant-directed humming and singing in lullaby style. To test the short-term effects of CMT on brain structure and function, diffusion tensor imaging data and resting-state functional imaging data were acquired. Clinical feasibility was achieved despite moderate parental refusal mainly in the control group after randomization. 40 infants remained as final cohort for the MRI analysis. Structural brain connectivity appears to be moderately affected by CMT, structural connectomic analysis revealed increased integration in the posterior cingulate cortex only. Lagged resting-state MRI analysis showed lower thalamocortical processing delay, stronger functional networks, and higher functional integration in predominantly left prefrontal, supplementary motor, and inferior temporal brain regions in infants treated with CMT. This trial provides unique evidence that CMT has beneficial effects on functional brain activity and connectivity in networks underlying higher-order cognitive, socio-emotional, and motor functions in preterm infants. Our results indicate the potential of CMT to improve long-term neurodevelopmental outcomes in children born very preterm.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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