Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults
Martens CR, Rossman MJ, Mazzo MR, Jankowski LR, Nagy EE, Denman BA, Richey JJ, Johnson SA, Ziemba BP, Wang Y, Peterson CM, Chonchol M, Seals DR
GeroScience · 143 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (AG-000279); National Institute on Aging (AG053009); National Institute on Aging (F32 AG053009); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-056336); National Institute on Aging (T32AG000279)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2020-01-23 · Geroscience · vol. 42 · número 2 · págs. 667–686
- Editorial
- Springer International Publishing
- Citado
- 181 citas · más que el 99% de estudios similares · 11.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 93 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Nutritional Studies and Diet
- Palabras clave
- time-restricted feeding, middle-aged adults, healthspan extension, cardiovascular function, glucose tolerance, endurance capacity, lean body mass, bone mineral density, hunger, dietary adherence, nutrient intake, safety and tolerability
- MeSH
- cardiovascular system, humans, caloric restriction, fasting, pilot projects, energy intake, aged, middle aged, female, male
13 autores
- Christopher R. Martens🇺🇸 · autor de correspondenciaUniversity of Colorado Boulder; University of Delaware
- Matthew J. Rossman🇺🇸University of Colorado Boulder
- Melissa R. Mazzo🇺🇸University of Colorado Boulder
- Lindsey R. Jankowski🇺🇸University of Colorado Boulder
- Erzsébet Nagy🇺🇸University of Colorado Boulder
- Blair A. Denman🇺🇸University of Colorado Boulder
- James J. Richey🇺🇸University of Colorado Boulder
- Sarah Johnson🇺🇸Colorado State University
- Brian P. Ziemba🇺🇸University of Colorado Boulder
- Yang Wang🇺🇸Colorado School of Public Health
- Courtney M. Peterson🇺🇸University of Alabama at Birmingham
- Michel Chonchol🇺🇸University of Colorado Anschutz; University of Colorado Denver
- Douglas R. Seals🇺🇸University of Colorado Boulder
Resumen
El texto original del estudio, en el idioma en que se publicó.
Chronic calorie restriction (CR) improves cardiovascular function and several other physiological markers of healthspan. However, CR is impractical in non-obese older humans due to potential loss of lean mass and bone density, poor adherence, and risk of malnutrition. Time-restricted feeding (TRF), which limits the daily feeding period without requiring a reduction in calorie intake, may be a promising alternative healthspan-extending strategy for midlife and older adults; however, there is limited evidence for its feasibility and efficacy in humans. We conducted a randomized, controlled pilot study to assess the safety, tolerability, and overall feasibility of short-term TRF (eating -1 for 6 weeks) without weight loss in healthy non-obese midlife and older adults, while gaining initial insight into potential efficacy for improving cardiovascular function and other indicators of healthspan. TRF was safe and well-tolerated, associated with excellent adherence and reduced hunger, and did not influence lean mass, bone density, or nutrient intake. Cardiovascular function was not enhanced by short-term TRF in this healthy cohort, but functional (endurance) capacity and glucose tolerance were modestly improved. These results provide a foundation for conducting larger clinical studies of TRF in midlife and older adults, including trials with a longer treatment duration.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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