Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial
Dusanov S, Svendsen M, Ruzzin J, Kiviranta H, Gulseth HL, Klemsdal TO, Tonstad S
Nutrition, metabolism, and cardiovascular diseases : NMCD · 12 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)
- Organización sin fines de lucro
- Nasjonalforeningen for Folkehelsen
- Organización sin fines de lucro
- EkstraStiftelsen Helse og Rehabilitering
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-11-21 · Nutr Metab Cardiovasc Dis · vol. 30 · número 3 · págs. 448–458
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 59% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Toxic Organic Pollutants Impact · Fatty Acid Research and Health · Per- and polyfluoroalkyl substances research
- Palabras clave
- persistent organic pollutants, fatty fish consumption, farmed salmon, nut consumption, overweight, obesity, cardiometabolic risk factors, HDL cholesterol, polychlorinated biphenyls, organochlorine compounds, dietary intervention
- MeSH
- animals, salmon, humans, nuts, obesity, organic chemicals, environmental pollutants, body mass index, diet, risk assessment, risk factors, consumer product safety, food contamination, nutritive value, time factors, fisheries, seafood, adult, aged, middle aged, norway, female, male
7 autores
- Sasa Dusanov🇳🇴 · autor de correspondenciaOslo University Hospital
- Mette Svendsen🇳🇴Oslo University Hospital; University of Oslo
- Jérôme Ruzzin🇳🇴University of Bergen
- Hannu Kiviranta
- Hanne Løvdal Gulseth🇳🇴Oslo University Hospital; Norwegian Institute of Public Health
- Tor Ole Klemsdal🇳🇴Oslo University Hospital
- Serena Tonstad🇳🇴Oslo University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
While excess energy intake and physical inactivity constitute the obvious causes of body fat accumulation, persistent organic pollutants (POPs) are novel factors that have been linked to cardiometabolic disorders. Major sources of POPs are animal fats including fatty fish. Given the putative protective effects of fish on cardiovascular disease, we explored whether high consumption of fatty fish increased serum concentrations of POPs.
Methods and results
Men and women aged 35-70 years with body mass index between 25 and 38 kg/m2 and at least 1 cardiometabolic component were randomized to high intakes of fatty fish (mostly farmed salmon, ∼630 g/week; n = 45), high intakes of nuts (∼200 g/week; n = 42) or a control group following their usual diet but restricting fatty fish and nuts for 6 months (n = 44). Concentrations of 15 POPs (5 organochlorinated compounds, 2 dioxin-like polychlorinated biphenyls and 8 non-dioxin-like polychlorinated biphenyls) and cardiometabolic risk factors were measured at baseline and end of the study. Results showed that changes in concentrations of individual and classes of POPs did not differ between the dietary groups and controls (p > 0.05). Among cardiometabolic risk factors HDL-cholesterol increased in the fatty fish group compared to controls (+0.10 mmol/L, CI (0.05-0.20); p = 0.005) while no changes were observed in the group consuming nuts.
Conclusion
Fatty fish consumption for 6 months did not increase the serum concentrations of POPs in individuals with overweight or obesity and metabolic risk. While this finding appears reassuring regarding short-term intakes of farmed salmon, long term variations in POPs in adipose stores require further study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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