Biological Responses of Stem Cells to Photobiomodulation Therapy
Khorsandi K, Hosseinzadeh R, Abrahamse H, Fekrazad R
Current stem cell research & therapy · 37 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-02-04 · Curr Stem Cell Res Ther · vol. 15 · número 5 · págs. 400–413
- Editorial
- Bentham Science Publishers
- Citado
- 53 citas · más que el 92% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 111 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research · Photodynamic Therapy Research Studies
- Palabras clave
- Stem cell, Regenerative medicine, Stem-cell therapy, Medicine, Adenosine triphosphate, Cell therapy, Mitochondrion, Cell biology, Reactive oxygen species, Mitochondrial respiratory chain, Induced pluripotent stem cell, Chemistry, Biology, Biochemistry, Internal medicine
- MeSH
- stem cells, animals, humans, regenerative medicine, signal transduction, low-level light therapy
4 autores
- Khatereh Khorsandi🇮🇷Academic Center for Education, Culture and Research; Universal Scientific Education and Research Network
- Reza Hosseinzadeh
- Heidi Abrahamse🇿🇦University of Johannesburg
- Reza Fekrazad🇮🇷 · autor de correspondenciaAja University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Stem cells have attracted the researchers interest, due to their applications in regenerative medicine. Their self-renewal capacity for multipotent differentiation, and immunomodulatory properties make them unique to significantly contribute to tissue repair and regeneration applications. Recently, stem cells have shown increased proliferation when irradiated with low-level laser therapy or Photobiomodulation Therapy (PBMT), which induces the activation of intracellular and extracellular chromophores and the initiation of cellular signaling. The purpose of this study was to evaluate this phenomenon in the literature.
Methods
The literature investigated the articles written in English in four electronic databases of PubMed, Scopus, Google Scholar and Cochrane up to April 2019. Stem cell was searched by combining the search keyword of "low-level laser therapy" OR "low power laser therapy" OR "low-intensity laser therapy" OR "photobiomodulation therapy" OR "photo biostimulation therapy" OR "LED". In total, 46 articles were eligible for evaluation.
Results
Studies demonstrated that red to near-infrared light is absorbed by the mitochondrial respiratory chain. Mitochondria are significant sources of reactive oxygen species (ROS). Mitochondria play an important role in metabolism, energy generation, and are also involved in mediating the effects induced by PBMT. PBMT may result in the increased production of (ROS), nitric oxide (NO), adenosine triphosphate (ATP), and cyclic adenosine monophosphate (cAMP). These changes, in turn, initiate cell proliferation and induce the signal cascade effect.
Conclusion
The findings of this review suggest that PBMT-based regenerative medicine could be a useful tool for future advances in tissue engineering and cell therapy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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