Dietary intake and biomarkers of linoleic acid and mortality: systematic review and meta-analysis of prospective cohort studies
Li J, Guasch-Ferré M, Li Y, Hu FB
The American journal of clinical nutrition · 94 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Diabetes Association
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL060712); National Institute of Diabetes and Digestive and Kidney Diseases (K99DK122128); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); American Diabetes Association (#1-18-PMF-029); National Institutes of Health (R01 HL60712); American Diabetes Association (9-17-CMF-011)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2020-01-01 · Am J Clin Nutr · vol. 112 · número 1 · págs. 150–167
- Editorial
- Elsevier BV
- Citado
- 128 citas · más que el 96% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 80 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Edible Oils Quality and Analysis
- Palabras clave
- linoleic acid, omega-6 fatty acids, dietary intake, mortality, cardiovascular mortality, cancer mortality, all-cause mortality, blood biomarkers, dietary assessment, baseline age, heterogeneity sources, prospective cohort, dietary fat intake, dietary fiber intake, cholesterol intake, sodium intake, protein intake
- MeSH
- humans, neoplasms, cardiovascular diseases, linoleic acid, fatty acids, omega-6, prospective studies, adult, aged, aged, 80 and over, middle aged, female, male, randomized controlled trials as topic, young adult
4 autores
- Jun Li🇺🇸Harvard University
- Marta Guasch‐Ferré🇺🇸Brigham and Women's Hospital; Harvard University
- Yanping Li🇺🇸Harvard University
- Frank B. Hu🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Current evidence on associations between intakes of linoleic acid (LA), the predominant n-6 (ω-6) fatty acid, and mortality is inconsistent and has not been summarized by a systematic review and meta-analysis.
Objective
The aim was to perform a systematic review and meta-analysis of prospective cohort studies to examine associations between LA intake and mortality.
Methods
We conducted a comprehensive search of MEDLINE and EMBASE databases through 31 July 2019 for prospective cohort studies reporting associations of LA (assessed by dietary surveys and/or LA concentrations in adipose tissue or blood compartments) with mortality from all causes, cardiovascular disease (CVD), and cancer. Multivariable-adjusted RRs were pooled using random-effects meta-analysis.
Results
Thirty-eight studies reporting 44 prospective cohorts were identified; these included 811,069 participants with dietary intake assessment (170,076 all-cause, 50,786 CVD, and 59,684 cancer deaths) and 65,411 participants with biomarker measurements (9758 all-cause, 6492 CVD, and 1719 cancer deaths). Pooled RRs comparing extreme categories of dietary LA intake (high vs low) were 0.87 (95% CI: 0.81, 0.94; I2 = 67.9%) for total mortality, 0.87 (95% CI: 0.82, 0.92; I2 = 3.7%) for CVD mortality, and 0.89 (95% CI: 0.85, 0.93; I2 = 0%) for cancer mortality. Pooled RRs for each SD increment in LA concentrations in adipose tissue/blood compartments were 0.91 (95% CI: 0.87, 0.95; I2 = 64.1%) for total mortality, 0.89 (95% CI: 0.85, 0.94; I2 = 28.9%) for CVD mortality, and 0.91 (95% CI: 0.84, 0.98; I2 = 26.3%) for cancer mortality. Meta-regressions suggested baseline age and dietary assessment methods as potential sources of heterogeneity for the association between LA and total mortality.
Conclusions
In prospective cohort studies, higher LA intake, assessed by dietary surveys or biomarkers, was associated with a modestly lower risk of mortality from all causes, CVD, and cancer. These data support the potential long-term benefits of PUFA intake in lowering the risk of CVD and premature death.
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