Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction
Litonjua AA, Carey VJ, Laranjo N, Stubbs BJ, Mirzakhani H, O'Connor GT, Sandel M, Beigelman A, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST
The New England journal of medicine · 140 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NIH HHS
- Gobierno
- NIH-NHLBI National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (K01 HL146977); National Heart, Lung, and Blood Institute (R01HL091528); National Heart, Lung, and Blood Institute (R01 HL091075); National Institutes of Health (UH3 OD023268); National Institute of Environmental Health Sciences (P30ES001247)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2020-02-05 · N Engl J Med · vol. 382 · número 6 · págs. 525–533
- Editorial
- Massachusetts Medical Society
- Citado
- 170 citas · más que el 100% de estudios similares · 16.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Birth, Development, and Health
- Palabras clave
- prenatal vitamin D supplementation, vitamin D3, asthma prevention, recurrent wheezing, childhood asthma, lung function, airway resistance, impulse oscillometry, spirometry, maternal nutrition
- MeSH
- lung, humans, asthma, respiratory sounds, vitamins, vitamin d, airway resistance, spirometry, prenatal care, incidence, follow-up studies, pregnancy, dietary supplements, child, female, intention to treat analysis
13 autores
- Augusto A. Litonjua🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Vincent J. Carey🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Nancy Laranjo🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Benjamin J. Stubbs🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Hooman Mirzakhani🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- George T. O’Connor🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Megan T. Sandel🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Avraham Beigelman🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; St. Louis Children's Hospital; Harvard University; Washington University in St. Louis; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Leonard B. Bacharier🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; St. Louis Children's Hospital; Harvard University; Washington University in St. Louis; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Robert S. Zeiger🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Kaiser Permanente; Harvard University; University of Rochester Medicine; Kaiser Permanente San Diego Medical Center; Golisano Children's Hospital; University of Rochester
- Michael N. Schatz🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Kaiser Permanente; Harvard University; University of Rochester Medicine; Kaiser Permanente San Diego Medical Center; Golisano Children's Hospital; University of Rochester
- Bruce W. Hollis🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; Medical University of South Carolina; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
- Scott T. Weiss🇺🇸Boston University; Brigham and Women's Hospital; Boston Medical Center; Harvard University; University of Rochester Medicine; Golisano Children's Hospital; University of Rochester
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We previously reported the results of a trial of prenatal vitamin D supplementation to prevent asthma and recurrent wheeze in young children, which suggested that supplementation provided a protective effect at the age of 3 years. We followed the children through the age of 6 years to determine the course of asthma and recurrent wheeze.
Methods
In this follow-up study, investigators and participants remained unaware of the treatment assignments through the children's sixth birthday. We aimed to determine whether, when maternal levels of 25-hydroxyvitamin D were taken into account, children born to mothers who had received 4400 IU of vitamin D3 per day during pregnancy (vitamin D group) would have a lower incidence of asthma and recurrent wheeze at the age of 6 years than would those born to mothers who had received 400 IU of vitamin D3 per day (control group). Time-to-event methods were used to compare the treatment groups with respect to time to the onset of asthma or recurrent wheeze. Multivariate methods were used to compare longitudinal measures of lung function between the treatment groups.
Results
There was no effect of maternal vitamin D supplementation on asthma and recurrent wheeze in either an intention-to-treat analysis or an analysis with stratification according to the maternal 25-hydroxyvitamin D level during pregnancy. There was no effect of prenatal vitamin D supplementation on most of the prespecified secondary outcomes. We found no effects of prenatal supplementation on spirometric indexes. Although there was a very small effect on airway resistance as measured by impulse oscillometry, this finding was of uncertain significance.
Conclusions
Vitamin D supplementation during the prenatal period alone did not influence the 6-year incidence of asthma and recurrent wheeze among children who were at risk for asthma. (Funded by the National Heart, Lung, and Blood Institute; VDAART ClinicalTrials.gov number, NCT00920621.).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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