Omega-3 fatty acid supplementation in pregnancy-baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial
Simmonds LA, Sullivan TR, Skubisz M, Middleton PF, Best KP, Yelland LN, Quinlivan J, Zhou SJ, Liu G, McPhee AJ, Gibson RA, Makrides M
BJOG : an international journal of obstetrics and gynaecology · 65 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Thyne Reid Foundation
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- Thyne Reid Foundation (1,061704); Thyne Reid Foundation (1046207); Thyne Reid Foundation (1052388); National Health and Medical Research Council (1135155); National Health and Medical Research Council (1046207); National Health and Medical Research Council (1052388); National Health and Medical Research Council (1061704); National Health and Medical Research Council (1050468)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2020-02-08 · BJOG · vol. 127 · número 8 · págs. 975–981
- Editorial
- Wiley
- Citado
- 102 citas · más que el 99% de estudios similares · 8.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Preterm Birth and Chorioamnionitis · Fatty Acid Research and Health · Gestational Diabetes Research and Management
- Palabras clave
- Pregnancy, Omega 3 fatty acid, Omega, Medicine, Randomized controlled trial, Obstetrics, Baseline (sea), Fatty acid, Gynecology, Docosahexaenoic acid, Internal medicine, Physics, Biology, Polyunsaturated fatty acid, Biochemistry
- MeSH
- humans, premature birth, fatty acids, omega-3, pregnancy outcome, prospective studies, gestational age, pregnancy, dietary supplements, adult, infant, newborn, australia, female, randomized controlled trials as topic
12 autores
- Lucy Simmonds🇦🇺South Australian Health and Medical Research Institute
- Thomas Sullivan🇦🇺South Australian Health and Medical Research Institute
- M. Skubisz🇦🇺Women's and Children's Hospital; South Australian Health and Medical Research Institute
- P.F. Middleton🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Karen P Best🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- LN Yelland🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Julie A. Quinlivan🇦🇺The University of Notre Dame Australia
- SJ Zhou🇦🇺The University of Adelaide
- G Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- AJ McPhee🇦🇺Women's and Children's Hospital; South Australian Health and Medical Research Institute
- Robert Alan Gibson🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- M Makrides🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To identify a polyunsaturated fatty acid (PUFA) biomarker able to detect which women with singleton pregnancies are most likely to benefit from omega-3 supplementation to reduce their risk of early preterm birth.
Design
Exploratory analysis of a randomised controlled trial.
Setting
Six Australian hospitals.
Population
Women with a singleton pregnancy enrolled in the ORIP trial.
Methods
Using maternal capillary whole blood collected ~14 weeks' gestation, the fatty acids in total blood lipids were quantified using gas chromatography. Interaction tests examined whether baseline PUFA status modified the effect of omega-3 supplementation on birth outcomes.
Main outcome measure
Early preterm birth (<34 weeks' gestation).
Results
A low total omega-3 PUFA status in early pregnancy was associated with a higher risk of early preterm birth. Among women with a total omega-3 status ≤4.1% of total fatty acids, omega-3 supplementation substantially reduced the risk of early preterm birth compared with control (0.73 versus 3.16%; relative risk = 0.23, 95% confidence interval [CI] 0.07-0.79). Conversely, women with higher total omega-3 status in early pregnancy were at lower risk of early preterm birth. Supplementing women with a baseline status above 4.9% increased early preterm birth (2.20 versus 0.97%; relative risk = 2.27, 95% CI 1.13-4.58).
Conclusions
Women with singleton pregnancies and low total omega-3 PUFA status early in pregnancy have an increased risk of early preterm birth and are most likely to benefit from omega-3 supplementation to reduce this risk. Women with higher total omega-3 status are at lower risk and additional omega-3 supplementation may increase their risk.
Tweetable abstract
Low total omega-3 fat status helps identify which women benefit from extra omega-3 to reduce early prematurity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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