Inhibitory Effects of Walnut (Juglans regia) Peptides on Neuroinflammation and Oxidative Stress in Lipopolysaccharide-Induced Cognitive Impairment Mice
Wang S, Zheng L, Zhao T, Zhang Q, Liu Y, Sun B, Su G, Zhao M
Journal of agricultural and food chemistry · 94 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-02-09 · J Agric Food Chem · vol. 68 · número 8 · págs. 2381–2392
- Editorial
- American Chemical Society
- Citado
- 138 citas · más que el 98% de estudios similares · 7.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Biochemical effects in animals · Protein Hydrolysis and Bioactive Peptides · Fatty Acid Research and Health
- Palabras clave
- Oxidative stress, Proinflammatory cytokine, Inflammation, Lipopolysaccharide, Neuroinflammation, Juglans, Neuroprotection, Chemistry, Pharmacology, Biochemistry, Immunology, Biology
- MeSH
- animals, humans, mice, juglans, nuts, lipopolysaccharides, peptides, neuroprotective agents, anti-inflammatory agents, maze learning, oxidative stress, molecular weight, cognitive dysfunction
8 autores
- Shuguang Wang🇨🇳South China University of Technology
- Lin Ping Zheng🇨🇳South China University of Technology
- Tiantian Zhao🇨🇳South China University of Technology
- Qi Zhang🇨🇳South China University of Technology
- Yang Liu🇨🇳South China University of Technology
- Baoguo Sun🇨🇳Beijing Technology and Business University; Beijing Advanced Innovation Center for Food Nutrition and Human Health
- Guowan Su🇨🇳 · autor de correspondenciaSouth China University of Technology
- Mouming Zhao🇨🇳 · autor de correspondenciaBeijing Technology and Business University; Beijing Advanced Innovation Center for Food Nutrition and Human Health; South China University of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Increasing level of inflammation and oxidative stress could lead to memory impairment. The purpose of this study was to determine the neuroprotective effects of walnut peptides against memory deficits induced by lipopolysaccharide (LPS) in mice and further to explore the underlying anti-inflammatory mechanisms against LPS-elicited inflammation in BV-2 cells. Results showed that walnut protein hydrolysate (WPH) and its low-molecular-weight fraction (WPHL) could ameliorate the memory deficits induced by LPS via normalizing the inflammatory response and oxidative stress in brain, especially WPHL. Furthermore, 18 peptides with anti-inflammatory activities on LPS-activated BV-2 cells were identified from WPHL and it was found that Trp, Gly, and Leu residues in peptides might contribute to the anti-inflammation. Meanwhile, the strong anti-inflammatory effects of LPF, GVYY, and APTLW might be related to their hydrophobic and aromatic amino acid residues as well. LPF, GVYY, and APTLW could reduce the content of proinflammatory mediators and cytokines by downregulating related enzyme expressions and mRNA expressions. Additionally, ROS and mitochondria homeostasis might also contribute to their anti-inflammatory effects.
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