Microcirculatory Response to Photobiomodulation-Why Some Respond and Others Do Not: A Randomized Controlled Study
Gavish L, Hoffer O, Rabin N, Halak M, Shkilevich S, Shayovitz Y, Weizman G, Haim O, Gavish B, Gertz SD, Ovadia-Blechman Z
Lasers in surgery and medicine · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Rosetrees Trust
- Organización sin fines de lucro
- Rosetrees
- Subvenciones
- Rosetrees Trust (M140-F2)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-02-17 · Lasers Surg Med · vol. 52 · número 9 · págs. 863–872
- Editorial
- Wiley
- Citado
- 45 citas · más que el 92% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Biofield Effects and Biophysics · Photodynamic Therapy Research Studies
- Palabras clave
- low-level laser therapy, near-infrared light, red light, microcirculation, skin blood flow, skin temperature, capillary flow, tissue perfusion, wavelength dependence, interindividual variability, photoplethysmography, laser Doppler flowmetry, infrared thermography
- MeSH
- microcirculation, humans, laser-doppler flowmetry, prospective studies, infrared rays, adult, female, male, young adult, low-level light therapy
11 autores
- Lilach Gavish🇮🇱 · autor de correspondenciaHebrew University of Jerusalem; Israel Defense Forces Medical Corps
- Oshrit Hoffer🇮🇱Afeka College of Engineering
- Neta Rabin🇮🇱Afeka College of Engineering; Tel Aviv University
- Moshe Halak🇮🇱Sheba Medical Center
- Simon Shkilevich🇮🇱Afeka College of Engineering
- Yuval Shayovitz🇮🇱Afeka College of Engineering
- Gal Weizman🇮🇱Afeka College of Engineering
- Ortal Haim🇮🇱Afeka College of Engineering
- Benjamin Gavish
- S. David Gertz🇮🇱Hebrew University of Jerusalem; Israel Defense Forces Medical Corps
- Zehava Ovadia‐Blechman🇮🇱Afeka College of Engineering
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Photobiomodulation (PBM), a non-ionizing, non-thermal irradiation, used clinically to accelerate wound healing and inhibit pain, was previously shown to increase blood flow. However, some individuals respond to PBM, but others do not. The purpose of this study was to investigate factors affecting this patient-specific response using advanced, noninvasive methods for monitoring microcirculatory activity.
Study design/materials and methods
In this prospective, randomized controlled clinical trial (NCT03357523), 20 healthy non-smoking volunteers (10:10 males:females, 30 ± 8 years old) were randomized to receive either red- (633 nm and 70 W/cm2 ) or near-infrared light (830 nm and 55 mW/cm2 ) over the wrist for 5 minutes. Photoplethysmography, laser Doppler flowmetry, and thermal imaging were used to monitor palm microcirculatory blood volume, blood flow, and skin temperature, respectively, before, during, and 20 minutes after irradiation. Participants with skin temperature change ≥0.5°C from baseline were considered "responders".
Results
Near-infrared PBM was found to induce a 27% increase in microcirculatory flow that increased to 54% during the 20-minute follow-up period (P = 0.049 and P = 0.004, respectively), but red light PBM did not increase the median flow. Only 10 of 20 participants were responders by thermal imaging (i.e., ≥0.5°C from baseline), and their initial skin temperature was between 33 and 37.5°C. The non-responders had either "hot" hands (≥37.5°C) or "cold" hands (≤33°C). In responders, the meantime to 20% increase in microcirculatory blood volume and blood flow was less than 2.5 minutes after initiation of PBM irradiation.
Conclusions
We demonstrated that PBM induces arteriolar vasodilatation that results in both immediate and long-lasting increased capillary flow and tissue perfusion in healthy individuals. This response was wavelength-dependent and modified by skin temperature. These findings regarding physiological parameters associated with sensitivity or resistance to PBM provide information of direct relevance for patient-specific therapy. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.
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