Dietary creatine intake and depression risk among U.S. adults
Bakian AV, Huber RS, Scholl L, Renshaw PF, Kondo D
Translational psychiatry · 68 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- U.S. Department of Veterans Affairs
- Universidad u hospital
- Utah Science Technology and Research
- Gobierno
- National Institutes of Health
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- National Institute of Mental Health
- Gobierno
- NIH Clinical Center
- Gobierno
- NIMH NIH HHS
- Gobierno
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health
- Gobierno
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
- Subvenciones
- National Institutes of Health (5r33mh096858-05); National Institute of Mental Health (R33MH096858); U.S. Department of Health and Human Services (R33MH096858)
Según 10 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-02-03 · Transl Psychiatry · vol. 10 · número 1 · pág. 52
- Editorial
- Springer Nature
- Citado
- 93 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 83 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Eating Disorders and Behaviors · Diet and metabolism studies
- Palabras clave
- National Health and Nutrition Examination Survey, Medicine, Creatine, Depression (economics), Quartile, Creatine Monohydrate, Logistic regression, Odds ratio, Body mass index, Internal medicine, Confounding, Environmental health, Confidence interval
- MeSH
- humans, creatine, diet, nutrition surveys, cross-sectional studies, depression, adult, female
5 autores
- Amanda V. Bakian🇺🇸 · autor de correspondenciaUniversity of Utah
- Rebekah S. Huber🇺🇸University of Utah
- Lindsay S. Scholl🇺🇸University of Utah
- Perry Franklin Renshaw🇺🇸University of Utah; Mental Illness Research, Education and Clinical Centers
- Douglas G. Kondo🇺🇸University of Utah; Mental Illness Research, Education and Clinical Centers
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine monohydrate is actively being researched for its antidepressant effects, yet little is known about the link between dietary creatine and depression risk. This study examines the association between dietary creatine and depression in U.S. adults, using data from the 2005 to 2012 National Health and Nutrition Examination Survey (NHANES). Patient health questionnaire, dietary creatine intake and covariates were obtained on 22,692 NHANES participants ≥20 years of age. Depression prevalence was calculated within quartiles of dietary creatine intake. Adjusted logistic regression models were formulated to determine the relationship between dietary creatine intake and depression risk. Additional covariates included income to poverty ratio, race/ethnicity, sex, age, education level, body mass index, healthcare access, smoking status, physical activity, and antidepressant/anxiolytic medication use. Models were further stratified by sex, age group, and antidepressant/anxiolytic medication use. Depression prevalence was 10.23/100 persons (95% CI: 8.64-11.83) among NHANES participants in the lowest quartile of dietary creatine intake compared with 5.98/100 persons (95% CI: 4.97-6.98) among participants in the highest quartile (p < 0.001). An inverse association was measured between dietary creatine and depression (adjusted odds ratio (AOR) = 0.68, 95% CI: 0.52-0.88). Dietary creatine's negative association with depression was strongest in females (AOR = 0.62, 95% CI: 0.40-0.98), participants aged 20-39 years (AOR = 0.52, 95% CI: 0.34-0.79) and participants not taking antidepressant/anxiolytic medication (AOR = 0.58, 95% CI: 0.43-0.77). Study results indicate a significant negative relationship between dietary creatine and depression in a nationally representative adult cohort. Further research is warranted to investigate the role creatine plays in depression, particularly among women and across the lifespan.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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