Estudio de cohortes2020Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaAcceso abierto

The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Tong TYN, Appleby PN, Key TJ, Dahm CC, Overvad K, Olsen A, Tjønneland A, Katzke V, Kühn T, Boeing H, Karakatsani A, Peppa E, Trichopoulou A, Weiderpass E, Masala G, Grioni S, Panico S, Tumino R, Boer JMA, Verschuren WMM, Quirós JR, Agudo A, Rodríguez-Barranco M, Imaz L, Chirlaque MD, Moreno-Iribas C, Engström G, Sonestedt E, Lind M, Otten J, Khaw KT, Aune D, Riboli E, Wareham NJ, Imamura F, Forouhi NG, di Angelantonio E, Wood AM, Butterworth AS, Perez-Cornago A

European heart journal · 72 citas

Etiquetas de revisión

Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vida

Datos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.

Cómo se estudió

Diseño: Estudio de cohortes (indexado por PubMed)
Estudiado en: Personas
Resultado principal: Eventos clínicos como enfermedad o muerte
Consumo medido con: Cuestionario de frecuencia de consumo

Quién lo pagó

Financiación: Financiación independiente
Gobierno: World Health Organization
Gobierno: National Institute on Handicapped Research
Organización sin fines de lucro: Kræftens Bekæmpelse
Universidad u hospital: Deutsches Krebsforschungszentrum
Universidad u hospital: Centre International de Recherche sur le Cancer
Gobierno: National Research Council Sri Lanka
Organización sin fines de lucro: Wellcome Trust
Gobierno: Centres de Recerca de Catalunya
Organización sin fines de lucro: Cancer Research UK
Gobierno: National Institute for Health and Care Research
Organización sin fines de lucro: British Heart Foundation
Gobierno: European Commission
Gobierno: Institut National de la Santé et de la Recherche Médicale
Gobierno: Bundesministerium für Bildung und Forschung
Organización sin fines de lucro: Cancerfonden
Gobierno: Generalitat de Catalunya
Organización sin fines de lucro: Ligue Contre le Cancer
Gobierno: Vetenskapsrådet
Organización sin fines de lucro: Associazione Italiana per la Ricerca sul Cancro
Organización sin fines de lucro: Deutsche Krebshilfe
Universidad u hospital: Institut Gustave-Roussy
Organización sin fines de lucro: Hellenic Health Foundation
Gobierno: Sixth Framework Programme
Gobierno: Medical Research Council
Organización sin fines de lucro: World Cancer Research Fund
Gobierno: H2020 European Research Council
Gobierno: EU Sixth Framework Programme
Gobierno: Dutch Ministry of Public Health, Welfare and Sports
Organización sin fines de lucro: German Cancer Aid, German Cancer Research Center
Gobierno: MRC Epidemiology Unit Cambridge
Organización sin fines de lucro: Mutuelle Générale de l’Education Nationale
Organización sin fines de lucro: Our Planet Our Health, Livestock Environment and People
Universidad u hospital: EPIC-Oxford
Gobierno: Medical Research Council Epidemiology Unit
Organización sin fines de lucro: Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy
Gobierno: International Agency for Research on Cancer
Gobierno: European Research Council
Gobierno: European Union Framework 7
Gobierno: Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research
Organización sin fines de lucro: Ligue Contre le Cancer, Institut Gustave Roussy
Gobierno: National Institute for Health Research (NIHR)
Organización sin fines de lucro: Danish Cancer Society
Gobierno: National Research Council
Universidad u hospital: Biomedical Research Centre Cambridge: Nutrition, Diet, and Lifestyle Research Theme
Gobierno: Federal Ministry of Education and Research
Subvenciones: Vetenskapsrådet (14136); Hellenic Health Foundation (C8221/A19170); Medical Research Council (IS-BRC-1215-20014); Medical Research Council (MC_UU_12015/1); Medical Research Council (MC_UU_12015/5); Medical Research Council (M012190/1); Institut Gustave-Roussy (C570/A16491); Medical Research Council (1000143 (to EPIC‐Norfolk)); Cancerfonden (C8221/A19170); Deutsche Krebshilfe (14136); Cancer Research UK (C570/ A16491); National Institute for Health and Care Research (C8221/A19170); World Cancer Research Fund (14136); Cancer Research UK (14136 to EPIC-Norfolk); Ligue Contre le Cancer (MR/M012190/1); Medical Research Council (C570/A16491); Institut National de la Santé et de la Recherche Médicale (C570/A16491); Bundesministerium für Bildung und Forschung (1000143); Ligue Contre le Cancer (C570/A16491); World Cancer Research Fund (MR/M012190/1); Bundesministerium für Bildung und Forschung (14136); Institut Gustave-Roussy (MR/M012190/1); Ligue Contre le Cancer (C8221/A19170); Deutsche Krebshilfe (MR/M012190/1); Medical Research Council (MC_UU_12015/5); Deutsches Krebsforschungszentrum (C8221/A19170); World Cancer Research Fund (C8221/A19170); Medical Research Council (MC_UU_12015); Ligue Contre le Cancer (14136); National Institute for Health and Care Research ([IS-BRC-1215-20014); Cancer Research UK (C8221/A19170 to EPIC‐Oxford); Bundesministerium für Bildung und Forschung (C8221/A19170); Institut Gustave-Roussy (C8221/A19170); Medical Research Council (14136); Centre International de Recherche sur le Cancer (14136); Cancerfonden (14136); Medical Research Council (MR/M012190); Cancer Research UK (14136 (to EPIC‐Norfolk), C570/A16491 and C8221/A19170 (to EPIC‐Oxford)); World Cancer Research Fund (C570/A16491); Institut Gustave-Roussy (14136); Hellenic Health Foundation (C570/A16491); National Institute for Health and Care Research (BRC1215-20014); Institut Gustave-Roussy (1000143); World Cancer Research Fund (1000143); National Institute for Health and Care Research (C570/A16491); Bundesministerium für Bildung und Forschung (MR/M012190/1); British Heart Foundation (G0800270); Hellenic Health Foundation (14136); Medical Research Council (C8221/A19170); European Commission (C570/A16491); European Commission (C8221/A19170); Associazione Italiana per la Ricerca sul Cancro (1000143); Medical Research Council (MR/L003120/1); Medical Research Council (1000143); Institut National de la Santé et de la Recherche Médicale (MR/M012190/1); European Commission (14136); Institut National de la Santé et de la Recherche Médicale (C8221/A19170); Medical Research Council (MR/M012190/1); British Heart Foundation (SP/09/002); Institut National de la Santé et de la Recherche Médicale (1000143); Deutsche Krebshilfe (C570/A16491); British Heart Foundation (RG/08/014); Centre International de Recherche sur le Cancer (MR/M012190/1); European Commission (1000143); Associazione Italiana per la Ricerca sul Cancro (MR/M012190/1); Centre International de Recherche sur le Cancer (1000143); Wellcome Trust (205212); Associazione Italiana per la Ricerca sul Cancro (14136); Cancer Research UK (BRC-1215-20014); European Commission (MR/M012190/1); H2020 European Research Council (268834); Institut National de la Santé et de la Recherche Médicale (14136); Medical Research Council (G0800270); Deutsche Krebshilfe (C8221/A19170); National Institute for Health and Care Research (MC_UU_12015/1); Cancer Research UK (14136); Cancer Research UK (1000143); Medical Research Council (MR/M012190/1); National Institute for Health and Care Research (NF-SI-0512-10114); National Institute for Health and Care Research (IS-BRC-1215); Cancer Research UK (MR/M012190/1); European Commission (279233); Medical Research Council (MR/N003284/1); Medical Research Council (BRC-1215-20014); National Institute for Health and Care Research (1000143); Centre International de Recherche sur le Cancer (C570/A16491); Cancer Research UK (C8221/A19170); Medical Research Council (MC_UU_12015/1); Wellcome Trust (People 205212/Z/16/Z); Associazione Italiana per la Ricerca sul Cancro (C570/A16491); Cancer Research UK (570/A16491); Deutsches Krebsforschungszentrum (C570/A16491); Ligue Contre le Cancer (1000143); Deutsches Krebsforschungszentrum (14136); British Heart Foundation (RG/13/13/30194); Hellenic Health Foundation (1000143); Cancerfonden (C570/A16491); Deutsche Krebshilfe (1000143); Wellcome Trust (BRC-1215-20014); Wellcome Trust (205212/Z/16/Z); Medical Research Council (MR/L003120); Vetenskapsrådet (1000143); Associazione Italiana per la Ricerca sul Cancro (C8221/A19170); Deutsches Krebsforschungszentrum (MR/M012190/1); Bundesministerium für Bildung und Forschung (C570/A16491); Centre International de Recherche sur le Cancer (C8221/A19170); Vetenskapsrådet (C8221/A19170); Hellenic Health Foundation (MR/M012190/1); National Institute for Health and Care Research (NF-SI-0617-10149); National Institute for Health and Care Research (MR/M012190/1); Vetenskapsrådet (C570/A16491); Sixth Framework Programme (LSHM_CT_2006_037197); British Heart Foundation (SP/09/002 and RG/08/014 and RG13/13/30194); Vetenskapsrådet (MR/M012190/1); Deutsches Krebsforschungszentrum (1000143); Cancer Research UK (MC-UU_12015/1); National Institute for Health and Care Research (14136); Medical Research Council (MR/M012190/1 to EPIC-Oxford); Medical Research Council (MR/L003120/1)

Según 45 financiadores declarados y la declaración de financiación del texto completo.

Publicación

Publicado: 2020-01-10 · Eur Heart J · vol. 41 · número 28 · págs. 2632–2640
Editorial: Oxford University Press
Citado: 92 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
Impacto: Entre el 10 % más citado de su campo
Referencias: 85 trabajos
Acceso: Acceso abierto (revista híbrida) · CC-BY
Áreas de investigación: Nutritional Studies and Diet · Dysphagia Assessment and Management · Nutrition and Health in Aging
Palabras clave: Medicine, Prospective cohort study, EPIC, Cohort, Stroke (engine), European Prospective Investigation into Cancer and Nutrition, Cohort study, Ischaemic stroke, Environmental health, Surgery, Internal medicine, Ischemia
MeSH: animals, humans, brain ischemia, diet, risk factors, prospective studies, dietary fiber, europe, female, male, stroke, hemorrhagic stroke

DOI ↗PubMed Central ↗OpenAlex ↗

40 autores

Tammy Y. N. Tong🇬🇧 · autor de correspondenciaUniversity of Oxford
Paul N. Appleby🇬🇧University of Oxford
Timothy J. Key🇬🇧University of Oxford
Christina Catherine Dahm🇩🇰Aarhus University
Kim Overvad🇩🇰Aarhus University; Aalborg University Hospital
Anja Olsen🇩🇰Danish Cancer Society
Anne Marie Tjønneland🇩🇰University of Copenhagen; Danish Cancer Society
Verena Andrea Katzke🇩🇪German Cancer Research Center; Heidelberg University
Tilman E. Kuhn🇩🇪German Cancer Research Center; Heidelberg University
Heiner Boeing🇩🇪German Institute of Human Nutrition
Anna Karakatsani🇬🇷National and Kapodistrian University of Athens; Hellenic Health Foundation
Eleni Peppa🇬🇷Hellenic Health Foundation
Antonia Trichopoulou🇬🇷Hellenic Health Foundation
Elisabete Weiderpass🇫🇷Centre international de recherche sur le cancer
Giovanna Masala🇺🇸Prevention Institute
Sara Grioni🇮🇹Fondazione IRCCS Istituto Nazionale dei Tumori
Salvatore Panico🇮🇹Federico II University Hospital
Rosario Tumino🇮🇹Azienda Usl 8 Arezzo
Jolanda M.A. Boer🇳🇱National Institute for Public Health and the Environment
W. M. Monique Verschuren🇳🇱🇩🇪Utrecht University; Heidelberg University; University Hospital Heidelberg; University Medical Center Utrecht; National Institute for Public Health and the Environment
José Ramón Quirós🇪🇸Gobierno del Principado de Asturias
Antonio Agudo🇪🇸Institut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia
Miguel Rodríguez‐Barranco🇪🇸Universidad de Granada; Instituto de Investigación Biosanitaria de Granada; Centro de Investigación Biomédica en Red; Andalusian School of Public Health
Liher Imaz🇪🇸Basque Government; Ministry of Health; Biogipuzkoa Health Research Institute
María‐Dolores Chirlaque🇪🇸Centro de Investigación Biomédica en Red; Instituto Murciano de Investigación Biosanitaria
Conchi Moreno‐Iribas🇪🇸Instituto de Salud Pública de Navarra; Centro de Investigación Biomédica en Red
Gunnar Engström🇸🇪Lund University
Emily Sonestedt🇸🇪Lund University
Marcus M. Lind🇸🇪Umeå University
Julia Otten🇸🇪Umeå University
Kay‐Tee Khaw🇬🇧University of Cambridge
Dagfinn Aune🇳🇴🇬🇧Oslo University Hospital; Oslo Nye Høyskole; Imperial College London
Elio Ríboli🇬🇧Imperial College London
Nicholas J. Wareham🇬🇧University of Cambridge; MRC Epidemiology Unit
Fumiaki Imamura🇬🇧University of Cambridge; MRC Epidemiology Unit
Nita G. Forouhi🇬🇧University of Cambridge; MRC Epidemiology Unit
Emanuele Di Angelantonio🇬🇧University of Cambridge
ANGELA M. WOOD🇬🇧University of Cambridge
Adam S. Butterworth🇬🇧University of Cambridge
Aurora Perez‐Cornago🇬🇧University of Oxford

Resumen

El texto original del estudio, en el idioma en que se publicó.

Aim

To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort.

Methods and results

We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82-0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69-0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91-0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85-0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81-0.97, P-trend = 0.008), while higher risk was observed with higher red meat consumption which attenuated when adjusted for the other statistically significant foods (per 50 g/day, 1.07; 0.96-1.20, P-trend = 0.20). For haemorrhagic stroke (1430 cases), higher risk was associated with higher egg consumption (per 20 g/day, 1.25; 1.09-1.43, P-trend = 0.002).

Conclusion

Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately.

Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).

Leer el texto completo ↗Ver en PubMed ↗

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