Magnesium intake and primary liver cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Zhong GC, Peng Y, Wang K, Wan L, Wu YQ, Hao FB, Hu JJ, Gu HT
International journal of cancer · 21 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-02-27 · Int J Cancer · vol. 147 · número 6 · págs. 1577–1586
- Editorial
- Wiley
- Citado
- 24 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 59 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Nutritional Studies and Diet
- Palabras clave
- Medicine, Hazard ratio, Incidence (geometry), Confidence interval, Proportional hazards model, Population, Internal medicine, Cohort study, Surgery, Environmental health
- MeSH
- humans, liver neoplasms, magnesium deficiency, magnesium, diet surveys, incidence, risk factors, survival analysis, follow-up studies, prospective studies, feeding behavior, dietary supplements, aged, middle aged, female, male, multicenter studies as topic, randomized controlled trials as topic, early detection of cancer
8 autores
- Guo‐Chao Zhong🇨🇳 · autor de correspondenciaDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Yang Peng🇨🇳Chengdu Fifth People's Hospital
- Kang Wang🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Lun Wan🇨🇳Chongqing Dazu District People's Hospital
- You‐Qi‐Le Wu🇨🇳Chongqing Public Health Medical Center; Chongqing Medical University
- Fa‐Bao Hao🇨🇳Qingdao University; Qingdao Women and Children's Hospital
- Jie‐Jun Hu🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Haitao Gu🇨🇳 · autor de correspondenciaDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiological studies on magnesium intake and primary liver cancer (PLC) are scarce, and no prospective studies have examined the associations of magnesium intake with PLC incidence and mortality. We sought to clarify whether higher magnesium intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population. Magnesium intake from diet and supplements was evaluated through a food frequency questionnaire in a cohort of 104,025 participants. Cox regression was employed to calculate hazard ratios for PLC incidence and competing risk regression was employed to calculate subdistribution hazard ratios for PLC mortality. Restricted cubic spline regression was employed to test nonlinearity. We documented 116 PLC cases during 1,193,513.5 person-years of follow-up and 100 PLC deaths during 1,198,021.3 person-years of follow-up. Total (diet + supplements) magnesium intake was found to be inversely associated with risks of PLC incidence (hazard ratiotertile 3 vs. 1 : 0.44; 95% confidence interval: 0.24, 0.80; ptrend = 0.0065) and mortality (subdistribution hazard ratiotertile 3 vs. 1 : 0.37; 95% confidence interval: 0.19, 0.71; ptrend = 0.0008). Similar results were obtained for dietary magnesium intake. Nonlinear inverse dose-response associations with PLC incidence and mortality were observed for both total and dietary magnesium intakes (all pnonlinearity < 0.05). In summary, in the US population, a high magnesium intake is associated with decreased risks of PLC incidence and mortality in a nonlinear dose-response manner. These findings support that increasing the consumption of foods rich in magnesium may be beneficial in reducing PLC incidence and mortality.
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