Photobiomodulation Therapy for Cancer Treatment-Related Salivary Gland Dysfunction: A Systematic Review
Heiskanen V, Zadik Y, Elad S
Photobiomodulation, photomedicine, and laser surgery · 27 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-02-28 · Photobiomodul Photomed Laser Surg · vol. 38 · número 6 · págs. 340–347
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 37 citas · más que el 78% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Salivary Gland Disorders and Functions · Laser Applications in Dentistry and Medicine
- Palabras clave
- low-level laser therapy, xerostomia, salivary gland hypofunction, cancer treatment side effects, head and neck cancer, chemoradiotherapy, hematopoietic stem cell transplantation
- MeSH
- humans, neoplasms, salivary gland diseases, antineoplastic agents, radiotherapy, low-level light therapy
3 autores
- Vladimir Heiskanen🇫🇮 · autor de correspondenciaUniversity of Helsinki
- Yehuda Zadik🇮🇱Hebrew University of Jerusalem
- Sharon Elad🇺🇸University of Rochester Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective: Symptoms and clinical signs of decreased saliva secretion are a common after cancer therapy. The goal of this research is to systematically review the evidence about the efficacy of photobiomodulation therapy (PBMT) for the management of cancer treatment-related xerostomia or salivary hypofunction. Methods: PubMed was searched for articles investigating the clinical effects of PBMT on cancer therapy-related xerostomia or hyposalivation. The publications that met the eligibility criteria were evaluated for the quality of the study design, physical parameter setting reproducibility, specifics of the treatment protocol, clinical outcomes, and adverse effects. The strongest evidence was given a heavier weight in the overall conclusions. Results: A total of 314 articles were identified, and 5 controlled trials were included in this systematic review. Most of the studies were in head and neck cancer patients treated with radiotherapy (RT) or radiochemotherapy (RT-CT), and one study was in dry mouth associated with hematopoietic stem cell transplantation (HSCT). Data showed conflicting results for either prevention or treatment of RT- or RT-CT-induced dry mouth or hyposalivation. The data for HSCT-related dry mouth were positive. Conclusions: Despite positive preliminary outcomes in most of the trials, it is too early to confidently determine the efficacy of PBM for cancer therapy-related hyposalivation or xerostomia.
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