Correlation Between Hashimoto's Thyroiditis-Related Thyroid Hormone Levels and 25-Hydroxyvitamin D
Chao G, Zhu Y, Fang L
Frontiers in endocrinology · 50 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Zhejiang Province
- Subvenciones
- National Natural Science Foundation of China (2015RCA020); Natural Science Foundation of Zhejiang Province (2016ZB071); Natural Science Foundation of Zhejiang Province (2015ZZ012); Natural Science Foundation of Zhejiang Province (2017KY413); National Natural Science Foundation of China (81973598); National Natural Science Foundation of China (2017ZA089); Natural Science Foundation of Zhejiang Province (LY18H030001); Natural Science Foundation of Zhejiang Province (81573760); Natural Science Foundation of Zhejiang Province (2017ZA089); National Natural Science Foundation of China (LY16H030010); Natural Science Foundation of Zhejiang Province (LY16H030010); Natural Science Foundation of Zhejiang Province (2014ZA030); National Natural Science Foundation of China (2017KY413); National Natural Science Foundation of China (LY18H030001); National Natural Science Foundation of China (2014ZA030); National Natural Science Foundation of China (81573760); Natural Science Foundation of Zhejiang Province (2015RCA020); National Natural Science Foundation of China (2015ZZ012); National Natural Science Foundation of China (2016ZB071); Natural Science Foundation of Zhejiang Province (81973598)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-02-14 · Front Endocrinol (Lausanne) · vol. 11 · pág. 4
- Editorial
- Frontiers Media
- Citado
- 68 citas · más que el 97% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Thyroid Disorders and Treatments · Thyroid Cancer Diagnosis and Treatment
- Palabras clave
- Medicine, Internal medicine, vitamin D deficiency, Thyroid peroxidase, Endocrinology, Thyroiditis, Vitamin D and neurology, Hormone, Iodine deficiency, Thyroid-stimulating hormone, Thyroid, Gastroenterology
- MeSH
- humans, hypertension, vitamin d deficiency, thyroid hormones, vitamin d, thyroid function tests, case-control studies, blood pressure, adult, middle aged, female, male, hashimoto disease
3 autores
- Guanqun Chao🇨🇳 · autor de correspondenciaSir Run Run Shaw Hospital; Zhejiang University
- Yue Zhu🇨🇳Sir Run Run Shaw Hospital; Zhejiang University
- Lizheng Fang🇨🇳 · autor de correspondenciaSir Run Run Shaw Hospital; Zhejiang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective: The purpose of this study was to further clarify the association of Hashimoto's thyroiditis (HT) and vitamin D deficiency, and to seek the connection between them and related influencing factors. Methods: Data were obtained from subjects who underwent health examinations from January 2018 to December 2018. The diagnosis of HT was based on: antithyroid peroxidase antibody (TPO-Ab) levels >35 IU/ml and/or antithyroglobulin antibody (Tg-Ab) levels >40 IU/ml. Based on the Endocrine Society guidelines, 25-hydroxyvitamin D [25(OH)D] levels ≥30.0 ng/ml were classified as a vitamin D sufficiency; those between 20 and 29.9 ng/ml, as an insufficiency; and those Results: Of a total of 75,436 individuals who were physically examined, 5,656 of them had 25(OH)D levels tested at the same time; 5,230 were enrolled. The level of 25(OH)D in the non-HT group was higher than that in the HT group. Multiple regression analysis showed that HT was statistically significantly correlated with being male, body mass index (BMI), waist circumference, and thyroid-stimulating hormone (TSH). TSH levels in the insufficiency group and deficiency group were higher than those in the sufficiency group. Free triiodothyronine (FT3) and thyroxine (FT4) levels in the insufficiency group and deficiency group were lower than those in the sufficiency group. 25(OH)D increased by 1 ng/ml at the normal reference level, with an increase of 2.78 ng/dl in FT4 concentration and a decrease of 0.17 mIU/L in TSH. Conclusions: Patients with HT present with a reduced 25(OH)D level, and TSH is an independent risk factor for HT. TSH is negatively correlated with 25(OH)D level. FT3 and FT4 levels were positively correlated with 25(OH)D levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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