Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis
Li Y, Ding S
BMC infectious diseases · 41 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-03-04 · BMC Infect Dis · vol. 20 · número 1 · pág. 189
- Editorial
- BioMed Central
- Citado
- 77 citas · más que el 96% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Adrenal Hormones and Disorders · Vitamin C and Antioxidants Research
- Palabras clave
- Medicine, Sepsis, Internal medicine, vitamin D deficiency, Relative risk, Vitamin D and neurology, Meta-analysis, Subgroup analysis, Systemic inflammatory response syndrome, Gastroenterology, Prospective cohort study, Lower risk, Risk of mortality, Confidence interval
- MeSH
- humans, sepsis, vitamin d deficiency, vitamin d, prognosis, incidence, risk, follow-up studies, adult, aged, middle aged, female, male
2 autores
- Yuye Li🇨🇳Shandong University; Shandong Chest Hospital
- Shifang Ding🇨🇳 · autor de correspondenciaQilu Hospital of Shandong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D deficiency has been related to the risk of sepsis. However, previous studies showed inconsistent results regarding the association between serum 25-hydroxyvitamin D (25 (OH) D) and mortality risk in septic patients. We aimed to evaluate the relationship between serum 25 (OH) D at admission and mortality risk in adult patients in a meta-analysis.
Methods
Follow-up studies that provided data of multivariate adjusted relative risk (RR) between serum 25 (OH) D and mortality risk in septic patients were retrieved via systematic search of PubMed and Embase databases. A random effect model was used to pool the results.
Results
Eight studies with 1736 patients were included. Results of overall meta-analysis showed that lower 25 (OH) D at admission was independently associated with increased risk or mortality (adjusted RR: 1.93, p 2 = 63%) in patients with sepsis. Exploring subgroup association showed that patients with severe vitamin D deficiency (25 (OH) D < 10 ng/ml) was significantly associated with higher mortality risk (adjusted RR: 1.92, p < 0.001), but the associations were not significant for vitamin D insufficiency (25 (OH) D 20~30 ng/ml) or deficiency (25 (OH) D 10~20 ng/ml). Further analyses showed that the association between lower serum 25 (OH) D and higher mortality risk were consistent in studies applied different diagnostic criteria for sepsis (systemic inflammatory response syndrome, Sepsis-2.0, or Sepsis-3.0), short-term (within 1 month) and long-term studies (3~12 months), and in prospective and retrospective studies.
Conclusions
Severe vitamin D deficiency may be independently associated with increased mortality in adult patients with sepsis. Large-scale prospective studies are needed to validate our findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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