Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study
Li ZH, Zhong WF, Liu S, Kraus VB, Zhang YJ, Gao X, Lv YB, Shen D, Zhang XR, Zhang PD, Huang QM, Chen Q, Wu XB, Shi XM, Wang D, Mao C
BMJ (Clinical research ed.) · 69 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (P30/AG028716); National Natural Science Foundation of China (81973109); National Institutes of Health (P30-AG-028716); National Institutes of Health (AG028716)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-03-04 · BMJ · vol. 368 · pág. m456
- Citado
- 102 citas · más que el 98% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Coenzyme Q10 studies and effects
- Palabras clave
- Medicine, Hazard ratio, Cohort, Fish oil, Prospective cohort study, Cohort study, Biobank, Confidence interval, Population, Demography, Internal medicine, Environmental health, Fish <Actinopterygii>, Biology, Bioinformatics
- MeSH
- humans, cardiovascular diseases, fish oils, risk factors, prospective studies, dietary supplements, adult, aged, middle aged, female, male, united kingdom
16 autores
- Zhihao Li🇨🇳Southern Medical University
- Wen-Fang Zhong🇨🇳Southern Medical University
- Simin Liu🇺🇸Brown University
- Virginia B. Kraus🇺🇸Duke University
- Yu-Jie Zhang🇨🇳Southern Medical University
- Xiang Gao🇺🇸Pennsylvania State University
- Yuebin Lv🇨🇳Chinese Center For Disease Control and Prevention
- Dong Shen🇨🇳Southern Medical University
- Xi-Ru Zhang🇨🇳Southern Medical University
- Peidong Zhang🇨🇳Southern Medical University
- Qing‐Mei Huang🇨🇳Southern Medical University
- Qing Chen🇨🇳Southern Medical University
- Xian-Bo Wu🇨🇳Southern Medical University
- Xiao‐Ming Shi🇨🇳Chinese Center For Disease Control and Prevention
- Dong Wang🇨🇳Southern Medical University
- Chen Mao🇨🇳 · autor de correspondenciaSouthern Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To evaluate the associations of habitual fish oil supplementation with cardiovascular disease (CVD) and mortality in a large prospective cohort.
Design
Population based, prospective cohort study.
Setting
UK Biobank.
Participants
A total of 427 678 men and women aged between 40 and 69 who had no CVD or cancer at baseline were enrolled between 2006 and 2010 and followed up to the end of 2018.
Main exposure
All participants answered questions on the habitual use of supplements, including fish oil.
Main outcome measures
All cause mortality, CVD mortality, and CVD events.
Results
At baseline, 133 438 (31.2%) of the 427 678 participants reported habitual use of fish oil supplements. The multivariable adjusted hazard ratios for habitual users of fish oil versus non-users were 0.87 (95% confidence interval 0.83 to 0.90) for all cause mortality, 0.84 (0.78 to 0.91) for CVD mortality, and 0.93 (0.90 to 0.96) for incident CVD events. For CVD events, the association seemed to be stronger among those with prevalent hypertension (P for interaction=0.005).
Conclusions
Habitual use of fish oil seems to be associated with a lower risk of all cause and CVD mortality and to provide a marginal benefit against CVD events among the general population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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